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Effects of Angiotensin-Converting Enzyme Inhibitor Derived from Tropaeolum majus L. in Rat Preimplantation Embryos: Evidence for the Dehydroepiandrosterone and Estradiol Role
المؤلفون المشاركون
Botelho Lourenço, Emerson Luiz
Muller, Juliane Centeno
Boareto, Ana Claudia
Gomes, Caroline
Lourenço, Ana Carolina
Calloi Palozi, Rhanany Alan
Lima Prando, Thiago Bruno
Gasparotto Junior, Arquimedes
Dalsenter, Paulo Roberto
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-20
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Although several studies have shown the inhibitory effects of Tropaeolum majus extracts (HETM) on angiotensin-converting enzyme (ACE) activity, no studies have been carried out during the beginning of pregnancy, when humoral and hormonal imbalance may affect zygote and early embryo transport.
This study investigates whether HETM can affect embryonic development when administered during the one-cell-blastocyst period.
Pregnant Wistar rats received orally the HETM (3, 30, and 300 mg/kg/day) from the 1st to the 7th gestational day.
Rats were killed on the 8th day of pregnancy and the following parameters were evaluated: clinical symptoms of toxicity (including organ weights), number of corpora lutea, implants per group, preimplantation losses ratio, and the serum levels of dehydroepiandrosterone (DHEA), estradiol, and progesterone.
No clinical symptoms of maternal toxicity were evidenced.
On the 8th day of pregnancy, the levels of DHEA and estradiol were increased and significant preimplantation losses were observed at all doses used.
The present study reveals that the HETM can raise levels of DHEA and estradiol and induce difficulty in the embryo implantation in the early stages of pregnancy.
The data contributes significantly to the safety aspects of using this natural product when trying to get pregnant or during pregnancy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Botelho Lourenço, Emerson Luiz& Muller, Juliane Centeno& Boareto, Ana Claudia& Gomes, Caroline& Lourenço, Ana Carolina& Calloi Palozi, Rhanany Alan…[et al.]. 2014. Effects of Angiotensin-Converting Enzyme Inhibitor Derived from Tropaeolum majus L. in Rat Preimplantation Embryos: Evidence for the Dehydroepiandrosterone and Estradiol Role. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018230
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Botelho Lourenço, Emerson Luiz…[et al.]. Effects of Angiotensin-Converting Enzyme Inhibitor Derived from Tropaeolum majus L. in Rat Preimplantation Embryos: Evidence for the Dehydroepiandrosterone and Estradiol Role. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1018230
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Botelho Lourenço, Emerson Luiz& Muller, Juliane Centeno& Boareto, Ana Claudia& Gomes, Caroline& Lourenço, Ana Carolina& Calloi Palozi, Rhanany Alan…[et al.]. Effects of Angiotensin-Converting Enzyme Inhibitor Derived from Tropaeolum majus L. in Rat Preimplantation Embryos: Evidence for the Dehydroepiandrosterone and Estradiol Role. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018230
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018230
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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