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Effects of Angiotensin-Converting Enzyme Inhibitor Derived from Tropaeolum majus L. in Rat Preimplantation Embryos: Evidence for the Dehydroepiandrosterone and Estradiol Role
Joint Authors
Botelho Lourenço, Emerson Luiz
Muller, Juliane Centeno
Boareto, Ana Claudia
Gomes, Caroline
Lourenço, Ana Carolina
Calloi Palozi, Rhanany Alan
Lima Prando, Thiago Bruno
Gasparotto Junior, Arquimedes
Dalsenter, Paulo Roberto
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Although several studies have shown the inhibitory effects of Tropaeolum majus extracts (HETM) on angiotensin-converting enzyme (ACE) activity, no studies have been carried out during the beginning of pregnancy, when humoral and hormonal imbalance may affect zygote and early embryo transport.
This study investigates whether HETM can affect embryonic development when administered during the one-cell-blastocyst period.
Pregnant Wistar rats received orally the HETM (3, 30, and 300 mg/kg/day) from the 1st to the 7th gestational day.
Rats were killed on the 8th day of pregnancy and the following parameters were evaluated: clinical symptoms of toxicity (including organ weights), number of corpora lutea, implants per group, preimplantation losses ratio, and the serum levels of dehydroepiandrosterone (DHEA), estradiol, and progesterone.
No clinical symptoms of maternal toxicity were evidenced.
On the 8th day of pregnancy, the levels of DHEA and estradiol were increased and significant preimplantation losses were observed at all doses used.
The present study reveals that the HETM can raise levels of DHEA and estradiol and induce difficulty in the embryo implantation in the early stages of pregnancy.
The data contributes significantly to the safety aspects of using this natural product when trying to get pregnant or during pregnancy.
American Psychological Association (APA)
Botelho Lourenço, Emerson Luiz& Muller, Juliane Centeno& Boareto, Ana Claudia& Gomes, Caroline& Lourenço, Ana Carolina& Calloi Palozi, Rhanany Alan…[et al.]. 2014. Effects of Angiotensin-Converting Enzyme Inhibitor Derived from Tropaeolum majus L. in Rat Preimplantation Embryos: Evidence for the Dehydroepiandrosterone and Estradiol Role. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018230
Modern Language Association (MLA)
Botelho Lourenço, Emerson Luiz…[et al.]. Effects of Angiotensin-Converting Enzyme Inhibitor Derived from Tropaeolum majus L. in Rat Preimplantation Embryos: Evidence for the Dehydroepiandrosterone and Estradiol Role. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1018230
American Medical Association (AMA)
Botelho Lourenço, Emerson Luiz& Muller, Juliane Centeno& Boareto, Ana Claudia& Gomes, Caroline& Lourenço, Ana Carolina& Calloi Palozi, Rhanany Alan…[et al.]. Effects of Angiotensin-Converting Enzyme Inhibitor Derived from Tropaeolum majus L. in Rat Preimplantation Embryos: Evidence for the Dehydroepiandrosterone and Estradiol Role. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018230