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Studies Based on Preparation, Physical Characteristics, and Cellular Pharmacological Activities of Thin PLGA Film Loaded with Geniposide
المؤلفون المشاركون
Zhang, Haiyan
Liu, Hao
Huang, Nan
He, Ya
Lei, Tingting
Wang, Xin
Yang, Ming
Luo, Guangming
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In this primary study, thin polylactic-co-glycolic acid (PLGA) film loaded with geniposide was first prepared and demonstrated on both physical and pharmacological aspects for its potential application on drug-eluting vascular stents.
Physical parameters of geniposide-loaded thin film, such as crystal structure, molecular spectral characteristics, and release behavior in the whole process were detected.
From X-Ray diffraction, the characteristic peak of crystal geniposide disappeared on geniposide-loaded PLGA film (GLPF) after it formed, which meant there was no agglomeration phenomenon, as geniposide was distributed in the form of single molecule.
According to scanning electron microscopy (SEM) figure, the GLPF was more flat and uniform with better compactness.
It inferred that release behavior of geniposide at the early stage (0~15 d) was in the form of free diffusion.
Carrier PLGA began to degrade 15 days later, so the residual geniposide was also dissolved.
Cellular pharmacological effects of geniposide on endothelial cells (ECs) and smooth muscle cells (SMCs) were also demonstrated on GLPF.
5% and 10% (w/w) geniposide-loaded PLGA (60 : 40) membrane indicated its significant effect on ECs promotion and SMCs inhibition.
All provided feasible evidences for the development of new geniposide-coating vascular stent using PLGA as carrier.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Haiyan& Liu, Hao& Huang, Nan& He, Ya& Lei, Tingting& Wang, Xin…[et al.]. 2014. Studies Based on Preparation, Physical Characteristics, and Cellular Pharmacological Activities of Thin PLGA Film Loaded with Geniposide. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018385
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Haiyan…[et al.]. Studies Based on Preparation, Physical Characteristics, and Cellular Pharmacological Activities of Thin PLGA Film Loaded with Geniposide. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1018385
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Haiyan& Liu, Hao& Huang, Nan& He, Ya& Lei, Tingting& Wang, Xin…[et al.]. Studies Based on Preparation, Physical Characteristics, and Cellular Pharmacological Activities of Thin PLGA Film Loaded with Geniposide. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018385
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018385
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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