Studies Based on Preparation, Physical Characteristics, and Cellular Pharmacological Activities of Thin PLGA Film Loaded with Geniposide
Joint Authors
Zhang, Haiyan
Liu, Hao
Huang, Nan
He, Ya
Lei, Tingting
Wang, Xin
Yang, Ming
Luo, Guangming
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In this primary study, thin polylactic-co-glycolic acid (PLGA) film loaded with geniposide was first prepared and demonstrated on both physical and pharmacological aspects for its potential application on drug-eluting vascular stents.
Physical parameters of geniposide-loaded thin film, such as crystal structure, molecular spectral characteristics, and release behavior in the whole process were detected.
From X-Ray diffraction, the characteristic peak of crystal geniposide disappeared on geniposide-loaded PLGA film (GLPF) after it formed, which meant there was no agglomeration phenomenon, as geniposide was distributed in the form of single molecule.
According to scanning electron microscopy (SEM) figure, the GLPF was more flat and uniform with better compactness.
It inferred that release behavior of geniposide at the early stage (0~15 d) was in the form of free diffusion.
Carrier PLGA began to degrade 15 days later, so the residual geniposide was also dissolved.
Cellular pharmacological effects of geniposide on endothelial cells (ECs) and smooth muscle cells (SMCs) were also demonstrated on GLPF.
5% and 10% (w/w) geniposide-loaded PLGA (60 : 40) membrane indicated its significant effect on ECs promotion and SMCs inhibition.
All provided feasible evidences for the development of new geniposide-coating vascular stent using PLGA as carrier.
American Psychological Association (APA)
Zhang, Haiyan& Liu, Hao& Huang, Nan& He, Ya& Lei, Tingting& Wang, Xin…[et al.]. 2014. Studies Based on Preparation, Physical Characteristics, and Cellular Pharmacological Activities of Thin PLGA Film Loaded with Geniposide. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018385
Modern Language Association (MLA)
Zhang, Haiyan…[et al.]. Studies Based on Preparation, Physical Characteristics, and Cellular Pharmacological Activities of Thin PLGA Film Loaded with Geniposide. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1018385
American Medical Association (AMA)
Zhang, Haiyan& Liu, Hao& Huang, Nan& He, Ya& Lei, Tingting& Wang, Xin…[et al.]. Studies Based on Preparation, Physical Characteristics, and Cellular Pharmacological Activities of Thin PLGA Film Loaded with Geniposide. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018385