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GBE50 Attenuates Inflammatory Response by Inhibiting the p38 MAPK and NF- κB Pathways in LPS-Stimulated Microglial Cells
المؤلفون المشاركون
He, Gai-ying
Yuan, Chong-gang
Hao, Li
Xu, Ying
Zhang, Zhi-xiong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Overactivated microglia contribute to a variety of pathological conditions in the central nervous system.
The major goal of the present study is to evaluate the potential suppressing effects of a new type of Ginko biloba extract, GBE50, on activated microglia which causes proinflammatory responses and to explore the underlying molecular mechanisms.
Murine BV2 microglia cells, with or without pretreatmentof GBE50 at various concentrations, were activated by incubation with lipopolysaccharide (LPS).
A series of biochemical and microscopic assays were performed to measure cell viability, cell morphology, release of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and signal transduction via the p38 MAPK and nuclear factor-kappa B (NF-κB) p65 pathways.
We found that GBE50 pretreatment suppressed LPS-induced morphological changes in BV2 cells.
Moreover, GBE50 treatment significantly reduced the release of proinflammatory cytokines, TNF-α and IL-1β, and inhibited the associated signal transduction through the p38 MAPK and NF-κB p65 pathways.
These results demonstrated the anti-inflammatory effect of GBE50 on LPS-activated BV2 microglia cells, and indicated that GBE50 reduced the LPS-induced proinflammatory TNF-α and IL-1β release by inhibiting signal transduction through the NF-κB p65 and p38 MAPK pathways.
Our findings reveal, at least in part, the molecular basis underlying the anti-inflammatory effects of GBE50.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Gai-ying& Yuan, Chong-gang& Hao, Li& Xu, Ying& Zhang, Zhi-xiong. 2014. GBE50 Attenuates Inflammatory Response by Inhibiting the p38 MAPK and NF- κB Pathways in LPS-Stimulated Microglial Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018396
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Gai-ying…[et al.]. GBE50 Attenuates Inflammatory Response by Inhibiting the p38 MAPK and NF- κB Pathways in LPS-Stimulated Microglial Cells. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1018396
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Gai-ying& Yuan, Chong-gang& Hao, Li& Xu, Ying& Zhang, Zhi-xiong. GBE50 Attenuates Inflammatory Response by Inhibiting the p38 MAPK and NF- κB Pathways in LPS-Stimulated Microglial Cells. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018396
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018396
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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