Puerarin Attenuates Cerebral Damage by Improving Cerebral Microcirculation in Spontaneously Hypertensive Rats
المؤلفون المشاركون
Wu, Xu-Dong
Wang, Chen
Zhang, Zhen-Ying
Fu, Yan
Liu, Feng-Ying
Liu, Xiu-Hua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Puerariae Lobatae Radix (Gegen in Chinese) is the dried root of Pueraria lobata, a semiwoody, perennial, and leguminous vine native to China.
Puerarin is one of the effective components of isoflavones isolated from the root of Pueraria lobata.
Previous studies showed that extracts derived from the root of Pueraria lobata possessed antihypertensive effect.
Our study is to investigate whether puerarin contributes to prevention of stroke by improving cerebral microcirculation in rats.
Materials and Methods.
Video microscopy and laser Doppler perfusion imaging on the pia mater were used to measure the diameter of microvessel and blood perfusion in 12-week old spontaneously hypertensive rats (SHRs) and age-matched normotensive WKY rats.
Histological alterations were observed by hematoxylin and eosin staining, and microvessel density in cerebral tissue was measured by immunohistochemical analysis with anti-Factor VIII antibody.
Cell proliferation was detected by [3H]-TdR incorporation, and activities of p42/44 mitogen activated protein kinases (p42/44 MAPKs) were detected by western blot analysis in cultured cerebral microvascular endothelial cells (MECs).
Results.
Intravenous injection of puerarin relaxed arterioles and increased the blood flow perfusion in the pia mater in SHRs.
Puerarin treatment for 14 days reduced the blood pressure to a normal level in SHRs ( P < 0.05 ) and increased the arteriole diameter in the pia mater significantly as compared with vehicle treatment.
Arteriole remodeling, edema, and ischemia in cerebral tissue were attenuated in puerarin-treated SHRs.
Microvessel density in cerebral tissue was greater with puerarin than with vehicle treatment.
Puerarin-treated MECs showed greater proliferation and p42/44 MAPKs activities than vehicle treatment.
Conclusions.
Puerarin possesses effects of antihypertension and stroke prevention by improved microcirculation in SHRs, which results from the increase in cerebral blood perfusion both by arteriole relaxation and p42/44 MAPKs-mediated angiogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Xu-Dong& Wang, Chen& Zhang, Zhen-Ying& Fu, Yan& Liu, Feng-Ying& Liu, Xiu-Hua. 2014. Puerarin Attenuates Cerebral Damage by Improving Cerebral Microcirculation in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018452
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Xu-Dong…[et al.]. Puerarin Attenuates Cerebral Damage by Improving Cerebral Microcirculation in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1018452
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Xu-Dong& Wang, Chen& Zhang, Zhen-Ying& Fu, Yan& Liu, Feng-Ying& Liu, Xiu-Hua. Puerarin Attenuates Cerebral Damage by Improving Cerebral Microcirculation in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018452
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018452
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر