Coptis chinensis and Myrobalan (Terminalia chebula) Can Synergistically Inhibit Inflammatory Response In Vitro and In Vivo
المؤلفون المشاركون
Cui, Enhui
Zhi, Xiaoyan
Chen, Ying
Gao, Yuanyuan
Fan, Yunpeng
Zhang, Weimin
Ma, Wuren
Hou, Weifeng
Guo, Chao
Song, Xiaoping
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
|Objectives.
To investigate the anti-inflammatory effect of Coptis chinensis plus myrobalan (CM) in vitro and in vivo.
Methods.
The inflammation in mouse peritoneal macrophages was induced by lipopolysaccharide (LPS).
Animal models were established by using ear swelling and paw edema of mouse induced by xylene and formaldehyde, respectively.
In vitro, cytotoxicity, the phagocytosis of macrophages, the levels of nitric oxide (NO), induced nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in cell supernatant were detected.
In vivo, swelling rate and edema inhibitory rate of ear and paw were observed using CM-treated mice.
Results.
At 150–18.75 μg·mL−1, CM had no cytotoxicity and could significantly promote the growth and the phagocytosis of macrophages and inhibit the overproduction of NO, iNOS, TNF-α, and IL-6 in macrophages induced by LPS.
In vivo, pretreatment with CM, the ear swelling, and paw edema of mice could be significantly inhibited in a dose-dependent manner, and the antiedema effect of CM at high dose was better than dexamethasone.
Conclusion.
Our results demonstrated that Coptis chinensis and myrobalan possessed synergistically anti-inflammatory activities in vitro and in vivo, which indicated that CM had therapeutic potential for the prevention and treatment of inflammation-mediated diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cui, Enhui& Zhi, Xiaoyan& Chen, Ying& Gao, Yuanyuan& Fan, Yunpeng& Zhang, Weimin…[et al.]. 2014. Coptis chinensis and Myrobalan (Terminalia chebula) Can Synergistically Inhibit Inflammatory Response In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018592
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cui, Enhui…[et al.]. Coptis chinensis and Myrobalan (Terminalia chebula) Can Synergistically Inhibit Inflammatory Response In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1018592
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cui, Enhui& Zhi, Xiaoyan& Chen, Ying& Gao, Yuanyuan& Fan, Yunpeng& Zhang, Weimin…[et al.]. Coptis chinensis and Myrobalan (Terminalia chebula) Can Synergistically Inhibit Inflammatory Response In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018592
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018592
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر