Coptis chinensis and Myrobalan (Terminalia chebula) Can Synergistically Inhibit Inflammatory Response In Vitro and In Vivo
Joint Authors
Cui, Enhui
Zhi, Xiaoyan
Chen, Ying
Gao, Yuanyuan
Fan, Yunpeng
Zhang, Weimin
Ma, Wuren
Hou, Weifeng
Guo, Chao
Song, Xiaoping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
|Objectives.
To investigate the anti-inflammatory effect of Coptis chinensis plus myrobalan (CM) in vitro and in vivo.
Methods.
The inflammation in mouse peritoneal macrophages was induced by lipopolysaccharide (LPS).
Animal models were established by using ear swelling and paw edema of mouse induced by xylene and formaldehyde, respectively.
In vitro, cytotoxicity, the phagocytosis of macrophages, the levels of nitric oxide (NO), induced nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in cell supernatant were detected.
In vivo, swelling rate and edema inhibitory rate of ear and paw were observed using CM-treated mice.
Results.
At 150–18.75 μg·mL−1, CM had no cytotoxicity and could significantly promote the growth and the phagocytosis of macrophages and inhibit the overproduction of NO, iNOS, TNF-α, and IL-6 in macrophages induced by LPS.
In vivo, pretreatment with CM, the ear swelling, and paw edema of mice could be significantly inhibited in a dose-dependent manner, and the antiedema effect of CM at high dose was better than dexamethasone.
Conclusion.
Our results demonstrated that Coptis chinensis and myrobalan possessed synergistically anti-inflammatory activities in vitro and in vivo, which indicated that CM had therapeutic potential for the prevention and treatment of inflammation-mediated diseases.
American Psychological Association (APA)
Cui, Enhui& Zhi, Xiaoyan& Chen, Ying& Gao, Yuanyuan& Fan, Yunpeng& Zhang, Weimin…[et al.]. 2014. Coptis chinensis and Myrobalan (Terminalia chebula) Can Synergistically Inhibit Inflammatory Response In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018592
Modern Language Association (MLA)
Cui, Enhui…[et al.]. Coptis chinensis and Myrobalan (Terminalia chebula) Can Synergistically Inhibit Inflammatory Response In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1018592
American Medical Association (AMA)
Cui, Enhui& Zhi, Xiaoyan& Chen, Ying& Gao, Yuanyuan& Fan, Yunpeng& Zhang, Weimin…[et al.]. Coptis chinensis and Myrobalan (Terminalia chebula) Can Synergistically Inhibit Inflammatory Response In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018592
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018592