Myrcia bella Leaf Extract Presents Hypoglycemic Activity via PI3kAkt Insulin Signaling Pathway
المؤلفون المشاركون
Vareda, Priscilla Maria Ponce
Saldanha, Luiz Leonardo
Camaforte, Nathalia Aparecida de Paula
Violato, Natalia Moretti
Dokkedal, Anne Lígia
Bosqueiro, José Roberto
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Species of Myrcia are used by indigenous people and in traditional communities in Brazil for the treatment of Diabetes mellitus.
We investigated the hypoglycemic effect of the extract of leaves of Myrcia bella in diabetic mice.
The chemical fingerprinting of the 70% EtOH extract characterized as main constituents flavonoid aglycones, flavonoid-O-glycosides, and acylated flavonoid-O-glycosides derivatives of quercetin and myricetin.
Mice were treated with saline or extract of M.
bella (300 or 600 mg/Kg b.w.) for 14 days.
Body weight and water and food intake were measured every day.
Fasting blood glucose was measured weekly.
At the end of the treatment, blood insulin, triglycerides, total cholesterol, and protein were measured.
Glycogen content and expression of proteins of the insulin signaling pathway were measured in liver.
The treatment with 600 mg/Kg reduced the fasting blood glucose in diabetic mice of the 7th day as water and food intake and increased hepatic glycogen.
Total cholesterol and triglycerides were reduced in diabetic treated mice.
The treatment increased the expression of IRS-1, PI3-K, and AKT in the livers of diabetic treated mice.
The results indicate that the extract of the leaves of Myrcia bella has hypoglycemic properties and possibly acts to regulate glucose uptake by the liver.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vareda, Priscilla Maria Ponce& Saldanha, Luiz Leonardo& Camaforte, Nathalia Aparecida de Paula& Violato, Natalia Moretti& Dokkedal, Anne Lígia& Bosqueiro, José Roberto. 2014. Myrcia bella Leaf Extract Presents Hypoglycemic Activity via PI3kAkt Insulin Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018623
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vareda, Priscilla Maria Ponce…[et al.]. Myrcia bella Leaf Extract Presents Hypoglycemic Activity via PI3kAkt Insulin Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1018623
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vareda, Priscilla Maria Ponce& Saldanha, Luiz Leonardo& Camaforte, Nathalia Aparecida de Paula& Violato, Natalia Moretti& Dokkedal, Anne Lígia& Bosqueiro, José Roberto. Myrcia bella Leaf Extract Presents Hypoglycemic Activity via PI3kAkt Insulin Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018623
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018623
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر