Myrcia bella Leaf Extract Presents Hypoglycemic Activity via PI3kAkt Insulin Signaling Pathway
Joint Authors
Vareda, Priscilla Maria Ponce
Saldanha, Luiz Leonardo
Camaforte, Nathalia Aparecida de Paula
Violato, Natalia Moretti
Dokkedal, Anne Lígia
Bosqueiro, José Roberto
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Species of Myrcia are used by indigenous people and in traditional communities in Brazil for the treatment of Diabetes mellitus.
We investigated the hypoglycemic effect of the extract of leaves of Myrcia bella in diabetic mice.
The chemical fingerprinting of the 70% EtOH extract characterized as main constituents flavonoid aglycones, flavonoid-O-glycosides, and acylated flavonoid-O-glycosides derivatives of quercetin and myricetin.
Mice were treated with saline or extract of M.
bella (300 or 600 mg/Kg b.w.) for 14 days.
Body weight and water and food intake were measured every day.
Fasting blood glucose was measured weekly.
At the end of the treatment, blood insulin, triglycerides, total cholesterol, and protein were measured.
Glycogen content and expression of proteins of the insulin signaling pathway were measured in liver.
The treatment with 600 mg/Kg reduced the fasting blood glucose in diabetic mice of the 7th day as water and food intake and increased hepatic glycogen.
Total cholesterol and triglycerides were reduced in diabetic treated mice.
The treatment increased the expression of IRS-1, PI3-K, and AKT in the livers of diabetic treated mice.
The results indicate that the extract of the leaves of Myrcia bella has hypoglycemic properties and possibly acts to regulate glucose uptake by the liver.
American Psychological Association (APA)
Vareda, Priscilla Maria Ponce& Saldanha, Luiz Leonardo& Camaforte, Nathalia Aparecida de Paula& Violato, Natalia Moretti& Dokkedal, Anne Lígia& Bosqueiro, José Roberto. 2014. Myrcia bella Leaf Extract Presents Hypoglycemic Activity via PI3kAkt Insulin Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018623
Modern Language Association (MLA)
Vareda, Priscilla Maria Ponce…[et al.]. Myrcia bella Leaf Extract Presents Hypoglycemic Activity via PI3kAkt Insulin Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1018623
American Medical Association (AMA)
Vareda, Priscilla Maria Ponce& Saldanha, Luiz Leonardo& Camaforte, Nathalia Aparecida de Paula& Violato, Natalia Moretti& Dokkedal, Anne Lígia& Bosqueiro, José Roberto. Myrcia bella Leaf Extract Presents Hypoglycemic Activity via PI3kAkt Insulin Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018623