Protective Effects of Bu-Shen-Huo-Xue Formula against 56 Nephrectomy-Induced Chronic Renal Failure in Rats
المؤلفون المشاركون
Lu, Jian-Rao
Han, Hai-Yan
Chen, Jie
Xiong, Chong-Xiang
Wang, Xin-Hua
Hu, Jing
Chen, Xiu-Feng
Ma, Li
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Chronic renal failure (CRF) is a serious disease related to increasing incidence and prevalence as well as decline in quality of life.
Bu-Shen-Huo-Xue formula (BSHX), one of traditional herbal formulations, has been clinically employed to treat CRF for decades, but the mechanisms involved have not been investigated.
In the present study, we investigated the effects of BSHX on some closely related parameters in 5/6 nephrectomy CRF rats.
Rats with CRF were divided into five groups, namely, one control group, one enalapril group, and three BSHX treatment groups (0.25, 0.5, and 1 g/kg · d).
The rats subjected to sham operation were used as a normal control.
After eight weeks of treatment, BSHX significantly decreased the levels of Scr and BUN, downregulated the mRNA expression levels of TGF- β 1 , CTGF, NF- κ B, TNF- α , and OPN, upregulated the mRNA expression of PPAR γ , and reduced in situ expression of fibronectin and laminins.
Histological findings also showed significant amelioration of the damaged renal tissue.
BSHX protects 5/6 nephrectomy rats against chronic renal failure probably via regulating the expression of TNF- α , NF- κ B, TGF- β 1 , CTGF, PPAR γ , OPN, fibronectin, and laminins and is useful for therapy of CRF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Jian-Rao& Han, Hai-Yan& Chen, Jie& Xiong, Chong-Xiang& Wang, Xin-Hua& Hu, Jing…[et al.]. 2014. Protective Effects of Bu-Shen-Huo-Xue Formula against 56 Nephrectomy-Induced Chronic Renal Failure in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018692
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Jian-Rao…[et al.]. Protective Effects of Bu-Shen-Huo-Xue Formula against 56 Nephrectomy-Induced Chronic Renal Failure in Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1018692
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Jian-Rao& Han, Hai-Yan& Chen, Jie& Xiong, Chong-Xiang& Wang, Xin-Hua& Hu, Jing…[et al.]. Protective Effects of Bu-Shen-Huo-Xue Formula against 56 Nephrectomy-Induced Chronic Renal Failure in Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018692
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018692
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر