Protective Effects of Bu-Shen-Huo-Xue Formula against 56 Nephrectomy-Induced Chronic Renal Failure in Rats
Joint Authors
Lu, Jian-Rao
Han, Hai-Yan
Chen, Jie
Xiong, Chong-Xiang
Wang, Xin-Hua
Hu, Jing
Chen, Xiu-Feng
Ma, Li
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chronic renal failure (CRF) is a serious disease related to increasing incidence and prevalence as well as decline in quality of life.
Bu-Shen-Huo-Xue formula (BSHX), one of traditional herbal formulations, has been clinically employed to treat CRF for decades, but the mechanisms involved have not been investigated.
In the present study, we investigated the effects of BSHX on some closely related parameters in 5/6 nephrectomy CRF rats.
Rats with CRF were divided into five groups, namely, one control group, one enalapril group, and three BSHX treatment groups (0.25, 0.5, and 1 g/kg · d).
The rats subjected to sham operation were used as a normal control.
After eight weeks of treatment, BSHX significantly decreased the levels of Scr and BUN, downregulated the mRNA expression levels of TGF- β 1 , CTGF, NF- κ B, TNF- α , and OPN, upregulated the mRNA expression of PPAR γ , and reduced in situ expression of fibronectin and laminins.
Histological findings also showed significant amelioration of the damaged renal tissue.
BSHX protects 5/6 nephrectomy rats against chronic renal failure probably via regulating the expression of TNF- α , NF- κ B, TGF- β 1 , CTGF, PPAR γ , OPN, fibronectin, and laminins and is useful for therapy of CRF.
American Psychological Association (APA)
Lu, Jian-Rao& Han, Hai-Yan& Chen, Jie& Xiong, Chong-Xiang& Wang, Xin-Hua& Hu, Jing…[et al.]. 2014. Protective Effects of Bu-Shen-Huo-Xue Formula against 56 Nephrectomy-Induced Chronic Renal Failure in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018692
Modern Language Association (MLA)
Lu, Jian-Rao…[et al.]. Protective Effects of Bu-Shen-Huo-Xue Formula against 56 Nephrectomy-Induced Chronic Renal Failure in Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1018692
American Medical Association (AMA)
Lu, Jian-Rao& Han, Hai-Yan& Chen, Jie& Xiong, Chong-Xiang& Wang, Xin-Hua& Hu, Jing…[et al.]. Protective Effects of Bu-Shen-Huo-Xue Formula against 56 Nephrectomy-Induced Chronic Renal Failure in Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018692