![](/images/graphics-bg.png)
Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats
المؤلفون المشاركون
Muniandy, Sekaran
Giribabu, Nelli
Srinivasarao, Nelli
Swapna Rekha, Somesula
Salleh, N.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Diabetes mellitus has been reported to affect functions of the hippocampus.
We hypothesized that Centella asiatica, a herb traditionally being used to improve memory, prevents diabetes-related hippocampal dysfunction.
Therefore, the aim of this study was to investigate the protective role of C.
asiatica on the hippocampus in diabetes.
Methods.
Streptozotocin- (STZ-) induced adult male diabetic rats received 100 and 200 mg/kg/day body weight (b.w) C.
asiatica leaf aqueous extract for four consecutive weeks.
Following sacrifice, hippocampus was removed and hippocampal tissue homogenates were analyzed for Na+/K+-, Ca2+- and Mg2+-ATPases activity levels.
Levels of the markers of inflammation (tumor necrosis factor, TNF-α; interleukin, IL-6; and interleukin, IL-1β) and oxidative stress (lipid peroxidation product: LPO, superoxide dismutase: SOD, catalase: CAT, and glutathione peroxidase: GPx) were determined.
The hippocampal sections were visualized for histopathological changes.
Results.
Administration of C.
asiatica leaf aqueous extract to diabetic rats maintained near normal ATPases activity levels and prevents the increase in the levels of inflammatory and oxidative stress markers in the hippocampus.
Lesser signs of histopathological changes were observed in the hippocampus of C.
asiatica leaf aqueous extract treated diabetic rats.
Conclusions.
C.
asiatica leaf protects the hippocampus against diabetes-induced dysfunction which could help to preserve memory in this condition.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Giribabu, Nelli& Srinivasarao, Nelli& Swapna Rekha, Somesula& Muniandy, Sekaran& Salleh, N.. 2014. Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018696
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Giribabu, Nelli…[et al.]. Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1018696
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Giribabu, Nelli& Srinivasarao, Nelli& Swapna Rekha, Somesula& Muniandy, Sekaran& Salleh, N.. Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018696
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018696
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)