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Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats
Joint Authors
Muniandy, Sekaran
Giribabu, Nelli
Srinivasarao, Nelli
Swapna Rekha, Somesula
Salleh, N.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetes mellitus has been reported to affect functions of the hippocampus.
We hypothesized that Centella asiatica, a herb traditionally being used to improve memory, prevents diabetes-related hippocampal dysfunction.
Therefore, the aim of this study was to investigate the protective role of C.
asiatica on the hippocampus in diabetes.
Methods.
Streptozotocin- (STZ-) induced adult male diabetic rats received 100 and 200 mg/kg/day body weight (b.w) C.
asiatica leaf aqueous extract for four consecutive weeks.
Following sacrifice, hippocampus was removed and hippocampal tissue homogenates were analyzed for Na+/K+-, Ca2+- and Mg2+-ATPases activity levels.
Levels of the markers of inflammation (tumor necrosis factor, TNF-α; interleukin, IL-6; and interleukin, IL-1β) and oxidative stress (lipid peroxidation product: LPO, superoxide dismutase: SOD, catalase: CAT, and glutathione peroxidase: GPx) were determined.
The hippocampal sections were visualized for histopathological changes.
Results.
Administration of C.
asiatica leaf aqueous extract to diabetic rats maintained near normal ATPases activity levels and prevents the increase in the levels of inflammatory and oxidative stress markers in the hippocampus.
Lesser signs of histopathological changes were observed in the hippocampus of C.
asiatica leaf aqueous extract treated diabetic rats.
Conclusions.
C.
asiatica leaf protects the hippocampus against diabetes-induced dysfunction which could help to preserve memory in this condition.
American Psychological Association (APA)
Giribabu, Nelli& Srinivasarao, Nelli& Swapna Rekha, Somesula& Muniandy, Sekaran& Salleh, N.. 2014. Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018696
Modern Language Association (MLA)
Giribabu, Nelli…[et al.]. Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1018696
American Medical Association (AMA)
Giribabu, Nelli& Srinivasarao, Nelli& Swapna Rekha, Somesula& Muniandy, Sekaran& Salleh, N.. Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018696
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018696