Antiviral Activity of Sulfated Polysaccharide of Adenanthera pavonina against Poliovirus in HEp-2 Cells
المؤلفون المشاركون
Godoi, Ananda Marques de
Faccin-Galhardi, Lígia Carla
Lopes, Nayara
Rechenchoski, Daniele Zendrini
de Almeida, Raimundo Rafael
Ricardo, Nágila Maria Pontes Silva
Nozawa, Carlos
Linhares, Rosa Elisa Carvalho
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-20
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Adenanthera pavonina, popularly known as red-bead tree, carolina, pigeon’s eye, and dragon’s eye, is a plant traditionally used in Brazil for the treatment of several diseases.
The present study aimed at evaluating the activity of sulfated polysaccharide from the Adenanthera pavonina (SPLSAp) seeds against poliovirus type 1 (PV-1) in HEp-2 cell cultures.
The SPLSAp presented a cytotoxic concentration (CC50) of 500 μg/mL in HEp-2 cell cultures, evaluated by the dimethylthiazolyl-diphenyltetrazolium bromide method (MTT).
The SPLSAp exhibited a significant antiviral activity, with a 50% inhibitory concentration (IC50) of 1.18 µg/mL, determined by plaque reduction assay and a high selectivity index (SI) of 423.
The maximum inhibition (100%) of PV replication was found when the SPLSAp treatment was concomitant with viral infection (time 0 h), at all tested concentrations.
The maximal inhibition was also found when the SPLSAp was used 1 h and 2 h postinfection, albeit at 50 μg/mL and 100 μg/mL.
Therefore, we demonstrated that the SPLSAp inhibited PV growth.
We also suggested that SPLSAp inhibited PV in more than one step of the replication, as the mechanism of antiviral action.
We, therefore, selected the compound as a potential candidate for further development towards the control of the infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Godoi, Ananda Marques de& Faccin-Galhardi, Lígia Carla& Lopes, Nayara& Rechenchoski, Daniele Zendrini& de Almeida, Raimundo Rafael& Ricardo, Nágila Maria Pontes Silva…[et al.]. 2014. Antiviral Activity of Sulfated Polysaccharide of Adenanthera pavonina against Poliovirus in HEp-2 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018934
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Godoi, Ananda Marques de…[et al.]. Antiviral Activity of Sulfated Polysaccharide of Adenanthera pavonina against Poliovirus in HEp-2 Cells. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1018934
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Godoi, Ananda Marques de& Faccin-Galhardi, Lígia Carla& Lopes, Nayara& Rechenchoski, Daniele Zendrini& de Almeida, Raimundo Rafael& Ricardo, Nágila Maria Pontes Silva…[et al.]. Antiviral Activity of Sulfated Polysaccharide of Adenanthera pavonina against Poliovirus in HEp-2 Cells. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018934
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018934
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر