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Antiviral Activity of Sulfated Polysaccharide of Adenanthera pavonina against Poliovirus in HEp-2 Cells
Joint Authors
Godoi, Ananda Marques de
Faccin-Galhardi, Lígia Carla
Lopes, Nayara
Rechenchoski, Daniele Zendrini
de Almeida, Raimundo Rafael
Ricardo, Nágila Maria Pontes Silva
Nozawa, Carlos
Linhares, Rosa Elisa Carvalho
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Adenanthera pavonina, popularly known as red-bead tree, carolina, pigeon’s eye, and dragon’s eye, is a plant traditionally used in Brazil for the treatment of several diseases.
The present study aimed at evaluating the activity of sulfated polysaccharide from the Adenanthera pavonina (SPLSAp) seeds against poliovirus type 1 (PV-1) in HEp-2 cell cultures.
The SPLSAp presented a cytotoxic concentration (CC50) of 500 μg/mL in HEp-2 cell cultures, evaluated by the dimethylthiazolyl-diphenyltetrazolium bromide method (MTT).
The SPLSAp exhibited a significant antiviral activity, with a 50% inhibitory concentration (IC50) of 1.18 µg/mL, determined by plaque reduction assay and a high selectivity index (SI) of 423.
The maximum inhibition (100%) of PV replication was found when the SPLSAp treatment was concomitant with viral infection (time 0 h), at all tested concentrations.
The maximal inhibition was also found when the SPLSAp was used 1 h and 2 h postinfection, albeit at 50 μg/mL and 100 μg/mL.
Therefore, we demonstrated that the SPLSAp inhibited PV growth.
We also suggested that SPLSAp inhibited PV in more than one step of the replication, as the mechanism of antiviral action.
We, therefore, selected the compound as a potential candidate for further development towards the control of the infection.
American Psychological Association (APA)
Godoi, Ananda Marques de& Faccin-Galhardi, Lígia Carla& Lopes, Nayara& Rechenchoski, Daniele Zendrini& de Almeida, Raimundo Rafael& Ricardo, Nágila Maria Pontes Silva…[et al.]. 2014. Antiviral Activity of Sulfated Polysaccharide of Adenanthera pavonina against Poliovirus in HEp-2 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018934
Modern Language Association (MLA)
Godoi, Ananda Marques de…[et al.]. Antiviral Activity of Sulfated Polysaccharide of Adenanthera pavonina against Poliovirus in HEp-2 Cells. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1018934
American Medical Association (AMA)
Godoi, Ananda Marques de& Faccin-Galhardi, Lígia Carla& Lopes, Nayara& Rechenchoski, Daniele Zendrini& de Almeida, Raimundo Rafael& Ricardo, Nágila Maria Pontes Silva…[et al.]. Antiviral Activity of Sulfated Polysaccharide of Adenanthera pavonina against Poliovirus in HEp-2 Cells. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018934