The Effect of Electroacupuncture on the Extracellular Matrix Synthesis and Degradation in a Rabbit Model of Disc Degeneration
المؤلفون المشاركون
Huang, Guo-fu
Zou, Jing
Shi, Jing
Zhang, Dong-you
Pen, Hong-fen
Zhang, Qi
Gao, Yu
Wang, Bo-yi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The present study was aimed at determining if the electroacupuncture (EA) is able to protect degenerated disc in vivo.
New Zealand white rabbits (n=40) were used for the study.
The rabbits were randomly assigned to four groups.
EA intervention was applied to one of the four groups.
Magnetic resonance imaging and Pfirrmann’s classification were obtained for each group to evaluate EA treatment on the intervertebral disc degeneration.
Discs were analyzed using immunofluorescence for the labeling of collagens 1 and 2, bone morphogenetic protein-2 (BMP-2), matrix metalloproteinase-13 (MMP-13), and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1).
For protein expression analysis, western blot was used for biglycan and decorin.
Outcomes indicated that EA intervention decreased the grades compared with the compressed disc.
Immunofluorescence analysis showed a significant increase of collagens 1 and 2, TIMP-1, and BMP-2 positive cells, in contrast to MMP-13 after EA treatment for 28 days.
The protein expression showed a sign of regeneration that decorin and biglycan were upregulated.
It was concluded that EA contributed to the extracellular matrix (ECM) anabolic processes and increased the ECM components.
MMPs and their inhibitors involved in the mechanism of EA intervention on ECM decreased disc.
It kept a dynamic balance between ECM synthesis and degradation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Guo-fu& Zou, Jing& Shi, Jing& Zhang, Dong-you& Pen, Hong-fen& Zhang, Qi…[et al.]. 2014. The Effect of Electroacupuncture on the Extracellular Matrix Synthesis and Degradation in a Rabbit Model of Disc Degeneration. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018982
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Guo-fu…[et al.]. The Effect of Electroacupuncture on the Extracellular Matrix Synthesis and Degradation in a Rabbit Model of Disc Degeneration. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1018982
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Guo-fu& Zou, Jing& Shi, Jing& Zhang, Dong-you& Pen, Hong-fen& Zhang, Qi…[et al.]. The Effect of Electroacupuncture on the Extracellular Matrix Synthesis and Degradation in a Rabbit Model of Disc Degeneration. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018982
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018982
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر