Cytotoxic Activities against Breast Cancer Cells of Local Justicia gendarussa Crude Extracts
المؤلفون المشاركون
Ayob, Zahidah
Mohd Bohari, Siti Pauliena
Abd Samad, Azman
Jamil, Shajarahtunnur
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-11
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Justicia gendarussa methanolic leaf extracts from five different locations in the Southern region of Peninsular Malaysia and two flavonoids, kaempferol and naringenin, were tested for cytotoxic activity.
Kaempferol and naringenin were two flavonoids detected in leaf extracts using gas chromatography-flame ionization detection (GC-FID).
The results indicated that highest concentrations of kaempferol and naringenin were detected in leaves extracted from Mersing with 1591.80 mg/kg and 444.35 mg/kg, respectively.
Positive correlations were observed between kaempferol and naringenin concentrations in all leaf extracts analysed with the Pearson method.
The effects of kaempferol and naringenin from leaf extracts were examined on breast cancer cell lines (MDA-MB-231 and MDA-MB-468) using MTT assay.
Leaf extract from Mersing showed high cytotoxicity against MDA-MB-468 and MDA-MB-231 with IC50 values of 23 μg/mL and 40 μg/mL, respectively, compared to other leaf extracts.
Kaempferol possessed high cytotoxicity against MDA-MB-468 and MDA-MB-231 with IC50 values of 23 μg/mL and 34 μg/mL, respectively.
These findings suggest that the presence of kaempferol in Mersing leaf extract contributed to high cytotoxicity of both MDA-MB-231 and MDA-MB-468 cancer cell lines.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ayob, Zahidah& Mohd Bohari, Siti Pauliena& Abd Samad, Azman& Jamil, Shajarahtunnur. 2014. Cytotoxic Activities against Breast Cancer Cells of Local Justicia gendarussa Crude Extracts. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018983
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ayob, Zahidah…[et al.]. Cytotoxic Activities against Breast Cancer Cells of Local Justicia gendarussa Crude Extracts. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1018983
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ayob, Zahidah& Mohd Bohari, Siti Pauliena& Abd Samad, Azman& Jamil, Shajarahtunnur. Cytotoxic Activities against Breast Cancer Cells of Local Justicia gendarussa Crude Extracts. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018983
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018983
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر