Cytotoxic Activities against Breast Cancer Cells of Local Justicia gendarussa Crude Extracts
Joint Authors
Ayob, Zahidah
Mohd Bohari, Siti Pauliena
Abd Samad, Azman
Jamil, Shajarahtunnur
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Justicia gendarussa methanolic leaf extracts from five different locations in the Southern region of Peninsular Malaysia and two flavonoids, kaempferol and naringenin, were tested for cytotoxic activity.
Kaempferol and naringenin were two flavonoids detected in leaf extracts using gas chromatography-flame ionization detection (GC-FID).
The results indicated that highest concentrations of kaempferol and naringenin were detected in leaves extracted from Mersing with 1591.80 mg/kg and 444.35 mg/kg, respectively.
Positive correlations were observed between kaempferol and naringenin concentrations in all leaf extracts analysed with the Pearson method.
The effects of kaempferol and naringenin from leaf extracts were examined on breast cancer cell lines (MDA-MB-231 and MDA-MB-468) using MTT assay.
Leaf extract from Mersing showed high cytotoxicity against MDA-MB-468 and MDA-MB-231 with IC50 values of 23 μg/mL and 40 μg/mL, respectively, compared to other leaf extracts.
Kaempferol possessed high cytotoxicity against MDA-MB-468 and MDA-MB-231 with IC50 values of 23 μg/mL and 34 μg/mL, respectively.
These findings suggest that the presence of kaempferol in Mersing leaf extract contributed to high cytotoxicity of both MDA-MB-231 and MDA-MB-468 cancer cell lines.
American Psychological Association (APA)
Ayob, Zahidah& Mohd Bohari, Siti Pauliena& Abd Samad, Azman& Jamil, Shajarahtunnur. 2014. Cytotoxic Activities against Breast Cancer Cells of Local Justicia gendarussa Crude Extracts. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018983
Modern Language Association (MLA)
Ayob, Zahidah…[et al.]. Cytotoxic Activities against Breast Cancer Cells of Local Justicia gendarussa Crude Extracts. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1018983
American Medical Association (AMA)
Ayob, Zahidah& Mohd Bohari, Siti Pauliena& Abd Samad, Azman& Jamil, Shajarahtunnur. Cytotoxic Activities against Breast Cancer Cells of Local Justicia gendarussa Crude Extracts. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018983