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Wen-Dan Decoction Improves Negative Emotions in Sleep-Deprived Rats by Regulating Orexin-A and Leptin Expression
المؤلفون المشاركون
Wu, Fengzhi
Song, Yuehan
Li, Feng
He, Xin
Ma, Jie
Feng, Ting
Guan, Binghe
Wang, Liye
Li, Sinai
Liu, Xiaolan
Liu, Yan
Mao, Meng
Liu, Jing
Bai, Shijing
Song, Cai
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Wen-Dan Decoction (WDD), a formula of traditional Chinese medicine, has been clinically used for treating insomnia for approximately 800 years.
However, the therapeutic mechanisms of WDD remain unclear.
Orexin-A plays a key role in the sleep-wake cycle, while leptin function is opposite to orexin-A.
Thus, orexin-A and leptin may be important factors in sleep disorders.
In this study, 48 rats were divided into control, model, WDD-treated, and diazepam-treated groups.
The model of insomnia was produced by sleep deprivation (SD) for 14 days.
The expressions of orexin-A, leptin, and their receptors in blood serum, prefrontal cortex, and hypothalamus were detected by enzyme-linked immunosorbent assay, immunohistochemistry, and real time PCR.
Open field tests showed that SD increased both crossing movement (Cm) and rearing-movement (Rm) times.
Orexin-A and leptin levels in blood serum increased after SD but decreased in brain compared to the control group.
mRNA expressions of orexin receptor 1 and leptin receptor after SD were decreased in the prefrontal cortex but were increased in hypothalamus.
WDD treatment normalized the behavior and upregulated orexin-A, leptin, orexin receptor 1 and leptin receptor in brain.
The findings suggest that WDD treatment may regulate SD-induced negative emotions by regulating orexin-A and leptin expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Fengzhi& Song, Yuehan& Li, Feng& He, Xin& Ma, Jie& Feng, Ting…[et al.]. 2014. Wen-Dan Decoction Improves Negative Emotions in Sleep-Deprived Rats by Regulating Orexin-A and Leptin Expression. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1020362
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Fengzhi…[et al.]. Wen-Dan Decoction Improves Negative Emotions in Sleep-Deprived Rats by Regulating Orexin-A and Leptin Expression. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1020362
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Fengzhi& Song, Yuehan& Li, Feng& He, Xin& Ma, Jie& Feng, Ting…[et al.]. Wen-Dan Decoction Improves Negative Emotions in Sleep-Deprived Rats by Regulating Orexin-A and Leptin Expression. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1020362
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1020362
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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