Valerian: No Evidence for Clinically Relevant Interactions
المؤلفون المشاركون
Kelber, Olaf
Nieber, Karen
Kraft, Karin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In recent popular publications as well as in widely used information websites directed to cancer patients, valerian is claimed to have a potential of adverse interactions with anticancer drugs.
This questions its use as a safe replacement for, for example, benzodiazepines.
A review on the interaction potential of preparations from valerian root (Valeriana officinalis L.
root) was therefore conducted.
A data base search and search in a clinical drug interaction data base were conducted.
Thereafter, a systematic assessment of publications was performed.
Seven in vitro studies on six CYP 450 isoenzymes, on p-glycoprotein, and on two UGT isoenzymes were identified.
However, the methodological assessment of these studies did not support their suitability for the prediction of clinically relevant interactions.
In addition, clinical studies on various valerian preparations did not reveal any relevant interaction potential concerning CYP 1A2, 2D6, 2E1, and 3A4.
Available animal and human pharmacodynamic studies did not verify any interaction potential.
The interaction potential of valerian preparations therefore seems to be low and thereby without clinical relevance.
We conclude that there is no specific evidence questioning their safety, also in cancer patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kelber, Olaf& Nieber, Karen& Kraft, Karin. 2014. Valerian: No Evidence for Clinically Relevant Interactions. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1020368
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kelber, Olaf…[et al.]. Valerian: No Evidence for Clinically Relevant Interactions. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1020368
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kelber, Olaf& Nieber, Karen& Kraft, Karin. Valerian: No Evidence for Clinically Relevant Interactions. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1020368
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1020368
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر