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Valerian: No Evidence for Clinically Relevant Interactions
Joint Authors
Kelber, Olaf
Nieber, Karen
Kraft, Karin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In recent popular publications as well as in widely used information websites directed to cancer patients, valerian is claimed to have a potential of adverse interactions with anticancer drugs.
This questions its use as a safe replacement for, for example, benzodiazepines.
A review on the interaction potential of preparations from valerian root (Valeriana officinalis L.
root) was therefore conducted.
A data base search and search in a clinical drug interaction data base were conducted.
Thereafter, a systematic assessment of publications was performed.
Seven in vitro studies on six CYP 450 isoenzymes, on p-glycoprotein, and on two UGT isoenzymes were identified.
However, the methodological assessment of these studies did not support their suitability for the prediction of clinically relevant interactions.
In addition, clinical studies on various valerian preparations did not reveal any relevant interaction potential concerning CYP 1A2, 2D6, 2E1, and 3A4.
Available animal and human pharmacodynamic studies did not verify any interaction potential.
The interaction potential of valerian preparations therefore seems to be low and thereby without clinical relevance.
We conclude that there is no specific evidence questioning their safety, also in cancer patients.
American Psychological Association (APA)
Kelber, Olaf& Nieber, Karen& Kraft, Karin. 2014. Valerian: No Evidence for Clinically Relevant Interactions. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1020368
Modern Language Association (MLA)
Kelber, Olaf…[et al.]. Valerian: No Evidence for Clinically Relevant Interactions. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1020368
American Medical Association (AMA)
Kelber, Olaf& Nieber, Karen& Kraft, Karin. Valerian: No Evidence for Clinically Relevant Interactions. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1020368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1020368