Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat)
المؤلفون المشاركون
Teixeira, Frederico
Mega, Cristina
Vala, Helena
Mascarenhas-Melo, Filipa
Teixeira de Lemos, Edite
Fernandes, Rosa
Oliveira, Jorge
Reis, Flávio
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
This study was performed to assess the effect of chronic low-dose sitagliptin, a dipeptidyl peptidase 4 inhibitor, on metabolic profile and on renal lesions aggravation in a rat model of type-2 diabetic nephropathy, the Zucker diabetic fatty (ZDF) rat.
Diabetic and obese ZDF (fa/fa) rats and their controls ZDF (+/+) were treated for 6 weeks with vehicle (control) or sitagliptin (10 mg/kg/bw).
Blood/serum glucose, HbA1c, insulin, Total-c, TGs, urea, and creatinine were assessed, as well as kidney glomerular and tubulointerstitial lesions (interstitial fibrosis/tubular atrophy), using a semiquantitative rating from 0 (absent/normal) to 3 (severe and extensive damage).
Vascular lesions were scored from 0–2.
Sitagliptin in the diabetic rats promoted an amelioration of glycemia, HbA1c, Total-c, and TGs, accompanied by a partial prevention of insulinopenia.
Furthermore, together with urea increment prevention, renal lesions were ameliorated in the diabetic rats, including glomerular, tubulointerstitial, and vascular lesions, accompanied by reduced lipid peroxidation.
In conclusion, chronic low-dose sitagliptin treatment was able to ameliorate diabetic nephropathy, which might represent a key step forward in the management of T2DM and this serious complication.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mega, Cristina& Teixeira de Lemos, Edite& Vala, Helena& Fernandes, Rosa& Oliveira, Jorge& Mascarenhas-Melo, Filipa…[et al.]. 2011. Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat). Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-1027673
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mega, Cristina…[et al.]. Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat). Journal of Diabetes Research No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-1027673
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mega, Cristina& Teixeira de Lemos, Edite& Vala, Helena& Fernandes, Rosa& Oliveira, Jorge& Mascarenhas-Melo, Filipa…[et al.]. Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat). Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-1027673
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1027673
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر