Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat)
Joint Authors
Teixeira, Frederico
Mega, Cristina
Vala, Helena
Mascarenhas-Melo, Filipa
Teixeira de Lemos, Edite
Fernandes, Rosa
Oliveira, Jorge
Reis, Flávio
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study was performed to assess the effect of chronic low-dose sitagliptin, a dipeptidyl peptidase 4 inhibitor, on metabolic profile and on renal lesions aggravation in a rat model of type-2 diabetic nephropathy, the Zucker diabetic fatty (ZDF) rat.
Diabetic and obese ZDF (fa/fa) rats and their controls ZDF (+/+) were treated for 6 weeks with vehicle (control) or sitagliptin (10 mg/kg/bw).
Blood/serum glucose, HbA1c, insulin, Total-c, TGs, urea, and creatinine were assessed, as well as kidney glomerular and tubulointerstitial lesions (interstitial fibrosis/tubular atrophy), using a semiquantitative rating from 0 (absent/normal) to 3 (severe and extensive damage).
Vascular lesions were scored from 0–2.
Sitagliptin in the diabetic rats promoted an amelioration of glycemia, HbA1c, Total-c, and TGs, accompanied by a partial prevention of insulinopenia.
Furthermore, together with urea increment prevention, renal lesions were ameliorated in the diabetic rats, including glomerular, tubulointerstitial, and vascular lesions, accompanied by reduced lipid peroxidation.
In conclusion, chronic low-dose sitagliptin treatment was able to ameliorate diabetic nephropathy, which might represent a key step forward in the management of T2DM and this serious complication.
American Psychological Association (APA)
Mega, Cristina& Teixeira de Lemos, Edite& Vala, Helena& Fernandes, Rosa& Oliveira, Jorge& Mascarenhas-Melo, Filipa…[et al.]. 2011. Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat). Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-1027673
Modern Language Association (MLA)
Mega, Cristina…[et al.]. Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat). Journal of Diabetes Research No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-1027673
American Medical Association (AMA)
Mega, Cristina& Teixeira de Lemos, Edite& Vala, Helena& Fernandes, Rosa& Oliveira, Jorge& Mascarenhas-Melo, Filipa…[et al.]. Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat). Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-1027673
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027673