The Antitumor Activity of Antrodia camphorata in Melanoma Cells: Modulation of Wntβ-Catenin Signaling Pathways
المؤلفون المشاركون
Chang, Hsueh-Wei
Hseu, You Cheng
Yang, Hsin-Ling
Tsou, Hsiao-Tung
Lin, Kai-Yuan
Kumar, K. J. Senthil
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-25
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Antrodia camphorata (AC) is well known in Taiwan as a traditional Chinese medicine.
The aim of this study was to investigate whether a fermented culture broth of AC could inhibit melanoma proliferation and progression via suppression of the Wnt/β-catenin signaling pathway.
In this study, we observed that AC treatment resulted in decreased cell viability and disturbed Wnt/β-catenin cascade in B16F10 and/or B16F1 melanoma cells.
This result was accompanied by a decrease in the expression of Wnt/β-catenin transcriptional targets, including c-Myc and survivin.
Furthermore, treatment of melanoma cells with AC resulted in a significant increase in apoptosis, which was associated with DNA fragmentation, cytochrome c release, caspase-9 and -3 activation, PARP degradation, Bcl-2/Bax dysregulation, and p53 expression.
We also observed that AC caused G1 phase arrest mediated by a downregulation of cyclin D1 and CDK4 and increased p21 and p27 expression.
In addition, we demonstrated that non- and subcytotoxic concentrations of AC markedly inhibited migration and invasion of highly metastatic B16F10 cells.
The antimetastatic effect of AC was further confirmed by reductions in the levels of MMP-2, MMP-9, and VEGF expression.
These results suggest that Antrodia camphorata may exert antitumor activity by downregulating the Wnt/β-catenin pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hseu, You Cheng& Tsou, Hsiao-Tung& Kumar, K. J. Senthil& Lin, Kai-Yuan& Chang, Hsueh-Wei& Yang, Hsin-Ling. 2012. The Antitumor Activity of Antrodia camphorata in Melanoma Cells: Modulation of Wntβ-Catenin Signaling Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1028165
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hseu, You Cheng…[et al.]. The Antitumor Activity of Antrodia camphorata in Melanoma Cells: Modulation of Wntβ-Catenin Signaling Pathways. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-1028165
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hseu, You Cheng& Tsou, Hsiao-Tung& Kumar, K. J. Senthil& Lin, Kai-Yuan& Chang, Hsueh-Wei& Yang, Hsin-Ling. The Antitumor Activity of Antrodia camphorata in Melanoma Cells: Modulation of Wntβ-Catenin Signaling Pathways. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1028165
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028165
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر