![](/images/graphics-bg.png)
In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis
المؤلفون المشاركون
Tam, Jacqueline Chor-Wing
Ko, Chun-Hay
Wong, Hing-Lok
Shum, Wai-Ting
Lau, Ching-Po
Cheng, Sau-Wan
Hung, Leung-Kim
Han, Quan-Bin
Leung, Ping-Chung
Siu, Wing Sum
Gao, Si
Lau, Clara Bik-San
Fung, Kwok Pui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Antiresorptive drugs, alendronate and raloxifene, are effective in lowering bone mineral density (BMD) loss in postmenopausal women.
However, long-term treatment may be associated with serious side effects.
Our research group has recently discovered that a Chinese herbal formula, ELP, could significantly reduce BMD loss in animal and human studies.
Therefore, the present study aimed to investigate the potential synergistic bone-protective effects of different herb-drug combinations using ovariectomized rats.
To assess the efficacy of different combinations, the total BMD was monitored biweekly in the 8-week course of daily oral treatment.
Bone microarchitecture, bone strength, and deoxypyridinoline level were also determined after 8 weeks.
From our results, coadministration of ELP and raloxifene increased the total tibial BMD by 5.26% (2.5 mg/kg/day of raloxifene; P=0.014) and 5.94% (0.25 mg/kg/day of raloxifene; P=0.026) when compared with the respective dosage groups with raloxifene alone.
Similar synergistic effects were also observed in BMD increase at distal femur (0.25 mg/kg/day; P=0.001) and reduction in urinary deoxypyridinoline crosslink excretion (2.5 and 0.25 mg/kg/day; both P=0.02).
However, such interactions could not be observed in all alendronate-treated groups.
Our data provide first evidence that ELP could synergistically enhance the therapeutic effects of raloxifene, so that the clinical dosage of raloxifene could be reduced.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ko, Chun-Hay& Siu, Wing Sum& Wong, Hing-Lok& Gao, Si& Shum, Wai-Ting& Lau, Ching-Po…[et al.]. 2012. In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028170
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ko, Chun-Hay…[et al.]. In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028170
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ko, Chun-Hay& Siu, Wing Sum& Wong, Hing-Lok& Gao, Si& Shum, Wai-Ting& Lau, Ching-Po…[et al.]. In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028170
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028170
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)