In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis
Joint Authors
Tam, Jacqueline Chor-Wing
Ko, Chun-Hay
Wong, Hing-Lok
Shum, Wai-Ting
Lau, Ching-Po
Cheng, Sau-Wan
Hung, Leung-Kim
Han, Quan-Bin
Leung, Ping-Chung
Siu, Wing Sum
Gao, Si
Lau, Clara Bik-San
Fung, Kwok Pui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Antiresorptive drugs, alendronate and raloxifene, are effective in lowering bone mineral density (BMD) loss in postmenopausal women.
However, long-term treatment may be associated with serious side effects.
Our research group has recently discovered that a Chinese herbal formula, ELP, could significantly reduce BMD loss in animal and human studies.
Therefore, the present study aimed to investigate the potential synergistic bone-protective effects of different herb-drug combinations using ovariectomized rats.
To assess the efficacy of different combinations, the total BMD was monitored biweekly in the 8-week course of daily oral treatment.
Bone microarchitecture, bone strength, and deoxypyridinoline level were also determined after 8 weeks.
From our results, coadministration of ELP and raloxifene increased the total tibial BMD by 5.26% (2.5 mg/kg/day of raloxifene; P=0.014) and 5.94% (0.25 mg/kg/day of raloxifene; P=0.026) when compared with the respective dosage groups with raloxifene alone.
Similar synergistic effects were also observed in BMD increase at distal femur (0.25 mg/kg/day; P=0.001) and reduction in urinary deoxypyridinoline crosslink excretion (2.5 and 0.25 mg/kg/day; both P=0.02).
However, such interactions could not be observed in all alendronate-treated groups.
Our data provide first evidence that ELP could synergistically enhance the therapeutic effects of raloxifene, so that the clinical dosage of raloxifene could be reduced.
American Psychological Association (APA)
Ko, Chun-Hay& Siu, Wing Sum& Wong, Hing-Lok& Gao, Si& Shum, Wai-Ting& Lau, Ching-Po…[et al.]. 2012. In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028170
Modern Language Association (MLA)
Ko, Chun-Hay…[et al.]. In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028170
American Medical Association (AMA)
Ko, Chun-Hay& Siu, Wing Sum& Wong, Hing-Lok& Gao, Si& Shum, Wai-Ting& Lau, Ching-Po…[et al.]. In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028170