Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in BalbC Mice
المؤلفون المشاركون
Ríos, José Luis
Andújar, Isabel
Giner, Rosa María
Miguel Cerdá, José
Recio, María del Carmen
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-31
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The naphthoquinone shikonin, a major component of the root of Lithospermum erythrorhizon, now is studied as an anti-inflammatory agent in the treatment of ulcerative colitis (UC).
Acute UC was induced in Balb/C mice by oral administration of 5% dextran sodium sulfate (DSS).
The disease activity index was evaluated, and a histologic study was carried out.
Orally administered shikonin reduces induced UC in a dose-dependent manner, preventing the shortening of the colorectum and decreasing weight loss by 5% while improving the appearance of feces and preventing bloody stools.
The disease activity index score was much lower in shikonin-treated mice than in the colitic group, as well as the myeloperoxidase activity.
The expression of cyclooxygenase-2 was reduced by 75%, activation of NF-κB was reduced by 44%, and that of pSTAT-3 by 47%, as well as TNF-α, IL-1β, and IL-6 production.
Similar results were obtained in primary macrophages culture.
This is the first report of shikonin’s ability to attenuate acute UC induced by DSS.
Shikonin acts by blocking the activation of two major targets: NF-κB and STAT-3, and thus constitutes a promising potential therapeutic agent for the management of the inflammatory bowel disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Andújar, Isabel& Ríos, José Luis& Giner, Rosa María& Miguel Cerdá, José& Recio, María del Carmen. 2012. Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in BalbC Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028211
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Andújar, Isabel…[et al.]. Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in BalbC Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-1028211
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Andújar, Isabel& Ríos, José Luis& Giner, Rosa María& Miguel Cerdá, José& Recio, María del Carmen. Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in BalbC Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028211
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028211
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر