Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in BalbC Mice
Joint Authors
Ríos, José Luis
Andújar, Isabel
Giner, Rosa María
Miguel Cerdá, José
Recio, María del Carmen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The naphthoquinone shikonin, a major component of the root of Lithospermum erythrorhizon, now is studied as an anti-inflammatory agent in the treatment of ulcerative colitis (UC).
Acute UC was induced in Balb/C mice by oral administration of 5% dextran sodium sulfate (DSS).
The disease activity index was evaluated, and a histologic study was carried out.
Orally administered shikonin reduces induced UC in a dose-dependent manner, preventing the shortening of the colorectum and decreasing weight loss by 5% while improving the appearance of feces and preventing bloody stools.
The disease activity index score was much lower in shikonin-treated mice than in the colitic group, as well as the myeloperoxidase activity.
The expression of cyclooxygenase-2 was reduced by 75%, activation of NF-κB was reduced by 44%, and that of pSTAT-3 by 47%, as well as TNF-α, IL-1β, and IL-6 production.
Similar results were obtained in primary macrophages culture.
This is the first report of shikonin’s ability to attenuate acute UC induced by DSS.
Shikonin acts by blocking the activation of two major targets: NF-κB and STAT-3, and thus constitutes a promising potential therapeutic agent for the management of the inflammatory bowel disease.
American Psychological Association (APA)
Andújar, Isabel& Ríos, José Luis& Giner, Rosa María& Miguel Cerdá, José& Recio, María del Carmen. 2012. Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in BalbC Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028211
Modern Language Association (MLA)
Andújar, Isabel…[et al.]. Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in BalbC Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-1028211
American Medical Association (AMA)
Andújar, Isabel& Ríos, José Luis& Giner, Rosa María& Miguel Cerdá, José& Recio, María del Carmen. Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in BalbC Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028211
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028211