6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2M Arrest
المؤلفون المشاركون
Lin, Chien-Hung
Lin, Ching-Bin
Tsay, Gregory J.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-07
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
6-Gingerol, a natural component of ginger, has been widely reported to possess antiinflammatory and antitumorigenic activities.
Despite its potential efficacy against cancer, the anti-tumor mechanisms of 6-gingerol are complicated and remain sketchy.
In the present study, we aimed to investigate the anti-tumor effects of 6-gingerol on colon cancer cells.
Our results revealed that 6-gingerol treatment significantly reduced the cell viability of human colon cancer cell, LoVo, in a dose-dependent manner.
Further flow cytometric analysis showed that 6-gingerol induced significant G2/M phase arrest and had slight influence on sub-G1 phase in LoVo cells.
Therefore, levels of cyclins, cyclin-dependent kinases (CDKs), and their regulatory proteins involved in S-G2/M transition were investigated.
Our findings revealed that levels of cyclin A, cyclin B1, and CDK1 were diminished; in contrast, levels of the negative cell cycle regulators p27Kip1 and p21Cip1 were increased in response to 6-gingerol treatment.
In addition, 6-gingerol treatment elevated intracellular reactive oxygen species (ROS) and phosphorylation level of p53.
These findings indicate that exposure of 6-gingerol may induce intracellular ROS and upregulate p53, p27Kip1, and p21Cip1 levels leading to consequent decrease of CDK1, cyclin A, and cyclin B1 as result of cell cycle arrest in LoVo cells.
It would be suggested that 6-gingerol should be beneficial to treatment of colon cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Ching-Bin& Lin, Chien-Hung& Tsay, Gregory J.. 2012. 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2M Arrest. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028258
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Ching-Bin…[et al.]. 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2M Arrest. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028258
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Ching-Bin& Lin, Chien-Hung& Tsay, Gregory J.. 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2M Arrest. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028258
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028258
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر