Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice

المؤلفون المشاركون

Sankian, Mojtaba
Taghiabadi, Elahe
Imenshahidi, Mohsen
Mosafa, Fatemeh
Karimi, Gholamreza
Abnous, Khalil
Memar, Bahram

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-12-18

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الطب البشري

الملخص EN

Reactive α,β-unsaturated aldehydes such as acrolein (ACR) are major components of environmental pollutants and have been implicated in the neurodegenerative and cardiac diseases.

In this study, the protective effect of silymarin (SN) against cardiotoxicity induced by ACR in mice was evaluated.

Studies were performed on seven groups of six animals each, including vehicle-control (normal saline + 0.5% w/v methylcellulose), ACR (7.5 mg/kg/day, gavage) for 3 weeks, SN (25, 50 and 100 mg/kg/day, i.p.) plus ACR, vitamin E (Vit E, 100 IU/kg, i.p.) plus ACR, and SN (100 mg/kg, i.p.) groups.

Mice received SN 7 days before ACR and daily thereafter throughout the study.

Pretreatment with SN attenuated ACR-induced increased levels of malondialdehyde (MDA), serum cardiac troponin I (cTnI), and creatine kinase-MB (CK-MB), as well as histopathological changes in cardiac tissues.

Moreover, SN improved glutathione (GSH) content, superoxide dismutase (SOD), and catalase (CAT) activities in heart of ACR-treated mice.

Western blot analysis showed that SN pretreatment inhibited apoptosis provoked by ACR through decreasing Bax/Bcl-2 ratio, cytosolic cytochrome c content, and cleaved caspase-3 level in heart.

In conclusion, SN may have protective effects against cardiotoxicity of ACR by reducing lipid peroxidation, renewing the activities of antioxidant enzymes, and preventing apoptosis.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Taghiabadi, Elahe& Imenshahidi, Mohsen& Abnous, Khalil& Mosafa, Fatemeh& Sankian, Mojtaba& Memar, Bahram…[et al.]. 2012. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1028266

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Taghiabadi, Elahe…[et al.]. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-1028266

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Taghiabadi, Elahe& Imenshahidi, Mohsen& Abnous, Khalil& Mosafa, Fatemeh& Sankian, Mojtaba& Memar, Bahram…[et al.]. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1028266

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1028266