Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice
المؤلفون المشاركون
Sankian, Mojtaba
Taghiabadi, Elahe
Imenshahidi, Mohsen
Mosafa, Fatemeh
Karimi, Gholamreza
Abnous, Khalil
Memar, Bahram
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-18
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Reactive α,β-unsaturated aldehydes such as acrolein (ACR) are major components of environmental pollutants and have been implicated in the neurodegenerative and cardiac diseases.
In this study, the protective effect of silymarin (SN) against cardiotoxicity induced by ACR in mice was evaluated.
Studies were performed on seven groups of six animals each, including vehicle-control (normal saline + 0.5% w/v methylcellulose), ACR (7.5 mg/kg/day, gavage) for 3 weeks, SN (25, 50 and 100 mg/kg/day, i.p.) plus ACR, vitamin E (Vit E, 100 IU/kg, i.p.) plus ACR, and SN (100 mg/kg, i.p.) groups.
Mice received SN 7 days before ACR and daily thereafter throughout the study.
Pretreatment with SN attenuated ACR-induced increased levels of malondialdehyde (MDA), serum cardiac troponin I (cTnI), and creatine kinase-MB (CK-MB), as well as histopathological changes in cardiac tissues.
Moreover, SN improved glutathione (GSH) content, superoxide dismutase (SOD), and catalase (CAT) activities in heart of ACR-treated mice.
Western blot analysis showed that SN pretreatment inhibited apoptosis provoked by ACR through decreasing Bax/Bcl-2 ratio, cytosolic cytochrome c content, and cleaved caspase-3 level in heart.
In conclusion, SN may have protective effects against cardiotoxicity of ACR by reducing lipid peroxidation, renewing the activities of antioxidant enzymes, and preventing apoptosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Taghiabadi, Elahe& Imenshahidi, Mohsen& Abnous, Khalil& Mosafa, Fatemeh& Sankian, Mojtaba& Memar, Bahram…[et al.]. 2012. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1028266
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Taghiabadi, Elahe…[et al.]. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-1028266
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Taghiabadi, Elahe& Imenshahidi, Mohsen& Abnous, Khalil& Mosafa, Fatemeh& Sankian, Mojtaba& Memar, Bahram…[et al.]. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1028266
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028266
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر