![](/images/graphics-bg.png)
Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice
Joint Authors
Sankian, Mojtaba
Taghiabadi, Elahe
Imenshahidi, Mohsen
Mosafa, Fatemeh
Karimi, Gholamreza
Abnous, Khalil
Memar, Bahram
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Reactive α,β-unsaturated aldehydes such as acrolein (ACR) are major components of environmental pollutants and have been implicated in the neurodegenerative and cardiac diseases.
In this study, the protective effect of silymarin (SN) against cardiotoxicity induced by ACR in mice was evaluated.
Studies were performed on seven groups of six animals each, including vehicle-control (normal saline + 0.5% w/v methylcellulose), ACR (7.5 mg/kg/day, gavage) for 3 weeks, SN (25, 50 and 100 mg/kg/day, i.p.) plus ACR, vitamin E (Vit E, 100 IU/kg, i.p.) plus ACR, and SN (100 mg/kg, i.p.) groups.
Mice received SN 7 days before ACR and daily thereafter throughout the study.
Pretreatment with SN attenuated ACR-induced increased levels of malondialdehyde (MDA), serum cardiac troponin I (cTnI), and creatine kinase-MB (CK-MB), as well as histopathological changes in cardiac tissues.
Moreover, SN improved glutathione (GSH) content, superoxide dismutase (SOD), and catalase (CAT) activities in heart of ACR-treated mice.
Western blot analysis showed that SN pretreatment inhibited apoptosis provoked by ACR through decreasing Bax/Bcl-2 ratio, cytosolic cytochrome c content, and cleaved caspase-3 level in heart.
In conclusion, SN may have protective effects against cardiotoxicity of ACR by reducing lipid peroxidation, renewing the activities of antioxidant enzymes, and preventing apoptosis.
American Psychological Association (APA)
Taghiabadi, Elahe& Imenshahidi, Mohsen& Abnous, Khalil& Mosafa, Fatemeh& Sankian, Mojtaba& Memar, Bahram…[et al.]. 2012. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1028266
Modern Language Association (MLA)
Taghiabadi, Elahe…[et al.]. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-1028266
American Medical Association (AMA)
Taghiabadi, Elahe& Imenshahidi, Mohsen& Abnous, Khalil& Mosafa, Fatemeh& Sankian, Mojtaba& Memar, Bahram…[et al.]. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1028266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028266