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Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing XylazineKetamine-Induced Anesthesia
المؤلفون المشاركون
Hsu, Hsin-Te
Lin, Ling-Hung
Wang, Kuo-Hsien
Lai, Chi-Yin
Chen, Chien-Ming
Ko, Wun-Chang
Shih, Chung-Hung
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Therefore, we were interested in investigating its effects on ovalbumin- (OVA-) induced airway hyperresponsiveness, and clarifying its rationale for ameliorating asthma and chronic obstructive pulmonary disease (COPD).
Hesperetin was revealed to have a therapeutic (PDE4H/PDE4L) ratio of >11.
Hesperetin (10 ~ 30 μmol/kg, intraperitoneally (i.p.)) dose-dependently and significantly attenuated the airway hyperresponsiveness induced by methacholine.
It also significantly suppressed the increases in total inflammatory cells, macrophages, lymphocytes, neutrophils, and eosinophils, and levels of cytokines, including interleukin (IL)-2, IL-4, IL-5, interferon-γ, and tumor necrosis factor-α in bronchoalveolar lavage fluid (BALF).
It dose-dependently and significantly suppressed total and OVA-specific immunoglobulin E levels in the BALF and serum.
However, hesperetin did not influence xylazine/ketamine-induced anesthesia, suggesting that hesperetin has few or no emetic effects.
In conclusion, the rationales for ameliorating allergic asthma and COPD by hesperetin are anti-inflammation, immunoregulation, and bronchodilation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shih, Chung-Hung& Lin, Ling-Hung& Wang, Kuo-Hsien& Lai, Chi-Yin& Chen, Chien-Ming& Ko, Wun-Chang…[et al.]. 2012. Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing XylazineKetamine-Induced Anesthesia. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028330
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shih, Chung-Hung…[et al.]. Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing XylazineKetamine-Induced Anesthesia. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028330
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shih, Chung-Hung& Lin, Ling-Hung& Wang, Kuo-Hsien& Lai, Chi-Yin& Chen, Chien-Ming& Ko, Wun-Chang…[et al.]. Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing XylazineKetamine-Induced Anesthesia. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028330
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028330
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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