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Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing XylazineKetamine-Induced Anesthesia
Joint Authors
Hsu, Hsin-Te
Lin, Ling-Hung
Wang, Kuo-Hsien
Lai, Chi-Yin
Chen, Chien-Ming
Ko, Wun-Chang
Shih, Chung-Hung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Therefore, we were interested in investigating its effects on ovalbumin- (OVA-) induced airway hyperresponsiveness, and clarifying its rationale for ameliorating asthma and chronic obstructive pulmonary disease (COPD).
Hesperetin was revealed to have a therapeutic (PDE4H/PDE4L) ratio of >11.
Hesperetin (10 ~ 30 μmol/kg, intraperitoneally (i.p.)) dose-dependently and significantly attenuated the airway hyperresponsiveness induced by methacholine.
It also significantly suppressed the increases in total inflammatory cells, macrophages, lymphocytes, neutrophils, and eosinophils, and levels of cytokines, including interleukin (IL)-2, IL-4, IL-5, interferon-γ, and tumor necrosis factor-α in bronchoalveolar lavage fluid (BALF).
It dose-dependently and significantly suppressed total and OVA-specific immunoglobulin E levels in the BALF and serum.
However, hesperetin did not influence xylazine/ketamine-induced anesthesia, suggesting that hesperetin has few or no emetic effects.
In conclusion, the rationales for ameliorating allergic asthma and COPD by hesperetin are anti-inflammation, immunoregulation, and bronchodilation.
American Psychological Association (APA)
Shih, Chung-Hung& Lin, Ling-Hung& Wang, Kuo-Hsien& Lai, Chi-Yin& Chen, Chien-Ming& Ko, Wun-Chang…[et al.]. 2012. Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing XylazineKetamine-Induced Anesthesia. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028330
Modern Language Association (MLA)
Shih, Chung-Hung…[et al.]. Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing XylazineKetamine-Induced Anesthesia. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028330
American Medical Association (AMA)
Shih, Chung-Hung& Lin, Ling-Hung& Wang, Kuo-Hsien& Lai, Chi-Yin& Chen, Chien-Ming& Ko, Wun-Chang…[et al.]. Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing XylazineKetamine-Induced Anesthesia. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028330