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Assessment of Anticholinesterase Activity of Gelidiella acerosa: Implications for Its Therapeutic Potential against Alzheimer’s Disease
المؤلفون المشاركون
Karutha Pandian, Shunmugiah
Syad, Arif Nisha
Kasi, Pandima Devi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The effect of various solvent extracts of Gelidiella acerosa on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities was investigated.
AChE and BuChE inhibitory activities were analyzed by spectrophotometric method.
Phytochemical screening of the compounds present in the solvent extracts was done qualitatively.
Characterization of the compounds present in the benzene extract of G.
acerosa was done by GC-MS analysis.
The results showed that, at 487.80 μg/mL, benzene extract showed significant (P<0.05) inhibitory activity against both AChE and BuChE with the percentage of inhibition 54.18±5.65 % (IC50 = 434.61±26.53 μg/mL) and 78.43±0% (IC50 = 163.01±85.35 μg/mL), respectively.
The mode of inhibition exhibited by benzene extract against the AChE and BuChE was found to be competitive and uncompetitive type of inhibition, respectively.
Preliminary phytochemical analysis coupled with GC-MS illustrates that the benzene extract possesses high amount of terpenoids, which could be the reason for potential cholinesterase inhibitory activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Syad, Arif Nisha& Karutha Pandian, Shunmugiah& Kasi, Pandima Devi. 2012. Assessment of Anticholinesterase Activity of Gelidiella acerosa: Implications for Its Therapeutic Potential against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028355
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Syad, Arif Nisha…[et al.]. Assessment of Anticholinesterase Activity of Gelidiella acerosa: Implications for Its Therapeutic Potential against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028355
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Syad, Arif Nisha& Karutha Pandian, Shunmugiah& Kasi, Pandima Devi. Assessment of Anticholinesterase Activity of Gelidiella acerosa: Implications for Its Therapeutic Potential against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028355
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028355
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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