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Assessment of Anticholinesterase Activity of Gelidiella acerosa: Implications for Its Therapeutic Potential against Alzheimer’s Disease
Joint Authors
Karutha Pandian, Shunmugiah
Syad, Arif Nisha
Kasi, Pandima Devi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The effect of various solvent extracts of Gelidiella acerosa on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities was investigated.
AChE and BuChE inhibitory activities were analyzed by spectrophotometric method.
Phytochemical screening of the compounds present in the solvent extracts was done qualitatively.
Characterization of the compounds present in the benzene extract of G.
acerosa was done by GC-MS analysis.
The results showed that, at 487.80 μg/mL, benzene extract showed significant (P<0.05) inhibitory activity against both AChE and BuChE with the percentage of inhibition 54.18±5.65 % (IC50 = 434.61±26.53 μg/mL) and 78.43±0% (IC50 = 163.01±85.35 μg/mL), respectively.
The mode of inhibition exhibited by benzene extract against the AChE and BuChE was found to be competitive and uncompetitive type of inhibition, respectively.
Preliminary phytochemical analysis coupled with GC-MS illustrates that the benzene extract possesses high amount of terpenoids, which could be the reason for potential cholinesterase inhibitory activity.
American Psychological Association (APA)
Syad, Arif Nisha& Karutha Pandian, Shunmugiah& Kasi, Pandima Devi. 2012. Assessment of Anticholinesterase Activity of Gelidiella acerosa: Implications for Its Therapeutic Potential against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028355
Modern Language Association (MLA)
Syad, Arif Nisha…[et al.]. Assessment of Anticholinesterase Activity of Gelidiella acerosa: Implications for Its Therapeutic Potential against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028355
American Medical Association (AMA)
Syad, Arif Nisha& Karutha Pandian, Shunmugiah& Kasi, Pandima Devi. Assessment of Anticholinesterase Activity of Gelidiella acerosa: Implications for Its Therapeutic Potential against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028355