Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo
المؤلفون المشاركون
Yu, Peng-Fei
Gou, Haitao
Zhu, Mei
Wang, Zhen-hua
Fu, Feng-hua
Tian, Jingwei
Zhang, Jianqiao
Wang, Hongbo
Jiang, Yongtao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Doxorubicin (DOX) is considered as one of the best antineoplastic agents.
However, its clinical use is restricted by its associated cardiotoxicity, which is mediated by the production of reactive oxygen species.
In this study, 20(S)-ginsenoside Rh2 (Rh2) was explored whether it had protective effects against DOX-induced cardiotoxicity.
In vitro study on H9C2 cell line, as well as in vivo investigation in one mouse and one rat model of DOX-induced cardiomyopathy, was carried out.
The results showed that pretreatment with Rh2 significantly increased the viability of DOX-injured H9C2 cells.
In the mouse model, Rh2 could suppress the DOX-induced release of the cardiac enzymes into serum and improved the occurred pathological changes through ameliorating the decreased antioxidant biomolecules and the cumulated lipid peroxidation malondialdehyde in heart tissues.
In the rat model, Rh2 could attenuate the change of ECG resulting from DOX administration.
Furthermore, Rh2 enhanced the antitumor activity of DOX in A549 cells.
Our findings thus demonstrated that Rh2 pretreatment could effectively alleviate heart injury induced by DOX, and Rh2 might act as a novel protective agent in the clinical usefulness of DOX.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Hongbo& Yu, Peng-Fei& Gou, Haitao& Zhang, Jianqiao& Zhu, Mei& Wang, Zhen-hua…[et al.]. 2012. Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028362
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Hongbo…[et al.]. Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028362
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Hongbo& Yu, Peng-Fei& Gou, Haitao& Zhang, Jianqiao& Zhu, Mei& Wang, Zhen-hua…[et al.]. Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028362
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028362
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر