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Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo
Joint Authors
Yu, Peng-Fei
Gou, Haitao
Zhu, Mei
Wang, Zhen-hua
Fu, Feng-hua
Tian, Jingwei
Zhang, Jianqiao
Wang, Hongbo
Jiang, Yongtao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Doxorubicin (DOX) is considered as one of the best antineoplastic agents.
However, its clinical use is restricted by its associated cardiotoxicity, which is mediated by the production of reactive oxygen species.
In this study, 20(S)-ginsenoside Rh2 (Rh2) was explored whether it had protective effects against DOX-induced cardiotoxicity.
In vitro study on H9C2 cell line, as well as in vivo investigation in one mouse and one rat model of DOX-induced cardiomyopathy, was carried out.
The results showed that pretreatment with Rh2 significantly increased the viability of DOX-injured H9C2 cells.
In the mouse model, Rh2 could suppress the DOX-induced release of the cardiac enzymes into serum and improved the occurred pathological changes through ameliorating the decreased antioxidant biomolecules and the cumulated lipid peroxidation malondialdehyde in heart tissues.
In the rat model, Rh2 could attenuate the change of ECG resulting from DOX administration.
Furthermore, Rh2 enhanced the antitumor activity of DOX in A549 cells.
Our findings thus demonstrated that Rh2 pretreatment could effectively alleviate heart injury induced by DOX, and Rh2 might act as a novel protective agent in the clinical usefulness of DOX.
American Psychological Association (APA)
Wang, Hongbo& Yu, Peng-Fei& Gou, Haitao& Zhang, Jianqiao& Zhu, Mei& Wang, Zhen-hua…[et al.]. 2012. Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028362
Modern Language Association (MLA)
Wang, Hongbo…[et al.]. Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028362
American Medical Association (AMA)
Wang, Hongbo& Yu, Peng-Fei& Gou, Haitao& Zhang, Jianqiao& Zhu, Mei& Wang, Zhen-hua…[et al.]. Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028362
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028362