The Molecular Basis of Wound Healing Processes Induced by Lithospermi Radix: A Proteomics and Biochemical Analysis
المؤلفون المشاركون
Hsiao, Chia-Yen
Chak, Kin-Fu
Tsai, Tung-Hu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-17
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Lithospermi Radix (LR) is an effective traditional Chinese herb in various types of wound healing; however, its mechanism of action remains unknown.
A biochemical and proteomic platform was generated to explore the biological phenomena associated with LR and its active component shikonin.
We found that both LR ethanol extracts and shikonin are able to promote cell proliferation by up to 25%.
The results of proteomic analysis revealed that twenty-two differentially expressed proteins could be identified when fibroblast cells were treated with LR or shikonin.
The functions of those proteins are associated with antioxidant activity, antiapoptosis activity, the regulation of cell mobility, the secretion of collagen, the removal of abnormal proteins, and the promotion of cell proliferation, indicating that the efficacy of LR in wound healing may be derived from a synergistic effect on a number of factors induced by the herbal medicine.
Furthermore, an animal model confirmed that LR is able to accelerate wound healing on the flank back of the SD rats.
Together these findings help to pinpoint the molecular basis of wound healing process induced by LR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hsiao, Chia-Yen& Tsai, Tung-Hu& Chak, Kin-Fu. 2012. The Molecular Basis of Wound Healing Processes Induced by Lithospermi Radix: A Proteomics and Biochemical Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028368
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hsiao, Chia-Yen…[et al.]. The Molecular Basis of Wound Healing Processes Induced by Lithospermi Radix: A Proteomics and Biochemical Analysis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-1028368
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hsiao, Chia-Yen& Tsai, Tung-Hu& Chak, Kin-Fu. The Molecular Basis of Wound Healing Processes Induced by Lithospermi Radix: A Proteomics and Biochemical Analysis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028368
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028368
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر