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The Molecular Basis of Wound Healing Processes Induced by Lithospermi Radix: A Proteomics and Biochemical Analysis
Joint Authors
Hsiao, Chia-Yen
Chak, Kin-Fu
Tsai, Tung-Hu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-17
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Lithospermi Radix (LR) is an effective traditional Chinese herb in various types of wound healing; however, its mechanism of action remains unknown.
A biochemical and proteomic platform was generated to explore the biological phenomena associated with LR and its active component shikonin.
We found that both LR ethanol extracts and shikonin are able to promote cell proliferation by up to 25%.
The results of proteomic analysis revealed that twenty-two differentially expressed proteins could be identified when fibroblast cells were treated with LR or shikonin.
The functions of those proteins are associated with antioxidant activity, antiapoptosis activity, the regulation of cell mobility, the secretion of collagen, the removal of abnormal proteins, and the promotion of cell proliferation, indicating that the efficacy of LR in wound healing may be derived from a synergistic effect on a number of factors induced by the herbal medicine.
Furthermore, an animal model confirmed that LR is able to accelerate wound healing on the flank back of the SD rats.
Together these findings help to pinpoint the molecular basis of wound healing process induced by LR.
American Psychological Association (APA)
Hsiao, Chia-Yen& Tsai, Tung-Hu& Chak, Kin-Fu. 2012. The Molecular Basis of Wound Healing Processes Induced by Lithospermi Radix: A Proteomics and Biochemical Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028368
Modern Language Association (MLA)
Hsiao, Chia-Yen…[et al.]. The Molecular Basis of Wound Healing Processes Induced by Lithospermi Radix: A Proteomics and Biochemical Analysis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-1028368
American Medical Association (AMA)
Hsiao, Chia-Yen& Tsai, Tung-Hu& Chak, Kin-Fu. The Molecular Basis of Wound Healing Processes Induced by Lithospermi Radix: A Proteomics and Biochemical Analysis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028368