Refined Qingkailing Protects MCAO Mice from Endoplasmic Reticulum Stress-Induced Apoptosis with a Broad Time Window
المؤلفون المشاركون
Zhong, Xiang-Gen
Cheng, Fafeng
Wang, Xueqian
Lu, Yi
Guo, Shaoying
Wang, Xiaotong
Liu, Dantong
Song, Wenting
Wang, Qingguo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
In the current study, we are investigating effect of refined QKL on ischemia-reperfusion-induced brain injury in mice.
Methods.
Mice were employed to induce ischemia-reperfusion injury of brain by middle cerebral artery occlusion (MCAO).
RQKL solution was administered with different doses (0, 1.5, 3, and 6 mL/kg body weight) at the same time of onset of ischemia, and with the dose of 1.5 mL/kg at different time points (0, 1.5, 3, 6, and 9 h after MCAO).
Neurological function and brain infarction were examined and cell apoptosis and ROS at prefrontal cortex were evaluated 24 h after MCAO, and western blot and intracellular calcium were also researched, respectively.
Results.
RQKL of all doses can improve neurological function and decrease brain infarction, and it performed significant effect in 0, 1.5, 3, and 6 h groups.
Moreover, RQKL was able to reduce apoptotic process by reduction of caspase-3 expression, or restraint of eIF2a phosphorylation and caspase-12 activation.
It was also able to reduce ROS and modulate intracellular calcium in the brain.
Conclusion.
RQKL can prevent ischemic-induced brain injury with a time window of 6 h, and its mechanism might be related to suppress ER stress-mediated apoptotic signaling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cheng, Fafeng& Zhong, Xiang-Gen& Lu, Yi& Wang, Xueqian& Song, Wenting& Guo, Shaoying…[et al.]. 2012. Refined Qingkailing Protects MCAO Mice from Endoplasmic Reticulum Stress-Induced Apoptosis with a Broad Time Window. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028397
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cheng, Fafeng…[et al.]. Refined Qingkailing Protects MCAO Mice from Endoplasmic Reticulum Stress-Induced Apoptosis with a Broad Time Window. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1028397
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cheng, Fafeng& Zhong, Xiang-Gen& Lu, Yi& Wang, Xueqian& Song, Wenting& Guo, Shaoying…[et al.]. Refined Qingkailing Protects MCAO Mice from Endoplasmic Reticulum Stress-Induced Apoptosis with a Broad Time Window. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028397
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028397
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر