From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound
المؤلفون المشاركون
Lee, Simon Ming-Yuen
Hung, Ming Wai
Zhang, Zai Jun
Li, Shang
Lei, Benson
Yuan, Shuai
Chan, Kelvin
Hoi, Pui-Man
Cui, Guozhen
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-05
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
The zebrafish (Danio rerio) has recently become a common model in the fields of genetics, environmental science, toxicology, and especially drug screening.
Zebrafish has emerged as a biomedically relevant model for in vivo high content drug screening and the simultaneous determination of multiple efficacy parameters, including behaviour, selectivity, and toxicity in the content of the whole organism.
A zebrafish behavioural assay has been demonstrated as a novel, rapid, and high-throughput approach to the discovery of neuroactive, psychoactive, and memory-modulating compounds.
Recent studies found a functional similarity of drug metabolism systems in zebrafish and mammals, providing a clue with why some compounds are active in zebrafish in vivo but not in vitro, as well as providing grounds for the rationales supporting the use of a zebrafish screen to identify prodrugs.
Here, we discuss the advantages of the zebrafish model for evaluating drug metabolism and the mode of pharmacological action with the emerging omics approaches.
Why this model is suitable for identifying lead compounds from natural products for therapy of disorders with multifactorial etiopathogenesis and imbalance of angiogenesis, such as Parkinson's disease, epilepsy, cardiotoxicity, cerebral hemorrhage, dyslipidemia, and hyperlipidemia, is addressed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hung, Ming Wai& Zhang, Zai Jun& Li, Shang& Lei, Benson& Yuan, Shuai& Cui, Guozhen…[et al.]. 2012. From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-1028420
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hung, Ming Wai…[et al.]. From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-1028420
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hung, Ming Wai& Zhang, Zai Jun& Li, Shang& Lei, Benson& Yuan, Shuai& Cui, Guozhen…[et al.]. From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-1028420
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028420
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر