From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound
Joint Authors
Lee, Simon Ming-Yuen
Hung, Ming Wai
Zhang, Zai Jun
Li, Shang
Lei, Benson
Yuan, Shuai
Chan, Kelvin
Hoi, Pui-Man
Cui, Guozhen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-05
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
The zebrafish (Danio rerio) has recently become a common model in the fields of genetics, environmental science, toxicology, and especially drug screening.
Zebrafish has emerged as a biomedically relevant model for in vivo high content drug screening and the simultaneous determination of multiple efficacy parameters, including behaviour, selectivity, and toxicity in the content of the whole organism.
A zebrafish behavioural assay has been demonstrated as a novel, rapid, and high-throughput approach to the discovery of neuroactive, psychoactive, and memory-modulating compounds.
Recent studies found a functional similarity of drug metabolism systems in zebrafish and mammals, providing a clue with why some compounds are active in zebrafish in vivo but not in vitro, as well as providing grounds for the rationales supporting the use of a zebrafish screen to identify prodrugs.
Here, we discuss the advantages of the zebrafish model for evaluating drug metabolism and the mode of pharmacological action with the emerging omics approaches.
Why this model is suitable for identifying lead compounds from natural products for therapy of disorders with multifactorial etiopathogenesis and imbalance of angiogenesis, such as Parkinson's disease, epilepsy, cardiotoxicity, cerebral hemorrhage, dyslipidemia, and hyperlipidemia, is addressed.
American Psychological Association (APA)
Hung, Ming Wai& Zhang, Zai Jun& Li, Shang& Lei, Benson& Yuan, Shuai& Cui, Guozhen…[et al.]. 2012. From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-1028420
Modern Language Association (MLA)
Hung, Ming Wai…[et al.]. From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-1028420
American Medical Association (AMA)
Hung, Ming Wai& Zhang, Zai Jun& Li, Shang& Lei, Benson& Yuan, Shuai& Cui, Guozhen…[et al.]. From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-1028420
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028420