Drug Target Prediction Based on the Herbs Components: The Study onthe Multitargets Pharmacological Mechanism of Qishenkeli Acting on the Coronary Heart Disease

المؤلفون المشاركون

Liu, Zhongyang
Li, Chun
Li, Dong
Ouyang, Yulin
Yu, Junda
Guo, Shuzhen
He, Fuchu
Wang, Wei
Wang, Yong

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-03-08

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

In this paper, we present a case study of Qishenkeli (QSKL) to research TCM’s underlying molecular mechanism, based on drug target prediction and analyses of TCM chemical components and following experimental validation.

First, after determining the compositive compounds of QSKL, we use drugCIPHER-CS to predict their potential drug targets.

These potential targets are significantly enriched with known cardiovascular disease-related drug targets.

Then we find these potential drug targets are significantly enriched in the biological processes of neuroactive ligand-receptor interaction, aminoacyl-tRNA biosynthesis, calcium signaling pathway, glycine, serine and threonine metabolism, and renin-angiotensin system (RAAS), and so on.

Then, animal model of coronary heart disease (CHD) induced by left anterior descending coronary artery ligation is applied to validate predicted pathway.

RAAS pathway is selected as an example, and the results show that QSKL has effect on both rennin and angiotensin II receptor (AT1R), which eventually down regulates the angiotensin II (AngII).

Bioinformatics combing with experiment verification can provide a credible and objective method to understand the complicated multitargets mechanism for Chinese herbal formula.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wang, Yong& Liu, Zhongyang& Li, Chun& Li, Dong& Ouyang, Yulin& Yu, Junda…[et al.]. 2012. Drug Target Prediction Based on the Herbs Components: The Study onthe Multitargets Pharmacological Mechanism of Qishenkeli Acting on the Coronary Heart Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028483

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wang, Yong…[et al.]. Drug Target Prediction Based on the Herbs Components: The Study onthe Multitargets Pharmacological Mechanism of Qishenkeli Acting on the Coronary Heart Disease. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028483

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wang, Yong& Liu, Zhongyang& Li, Chun& Li, Dong& Ouyang, Yulin& Yu, Junda…[et al.]. Drug Target Prediction Based on the Herbs Components: The Study onthe Multitargets Pharmacological Mechanism of Qishenkeli Acting on the Coronary Heart Disease. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028483

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1028483