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Drug Target Prediction Based on the Herbs Components: The Study onthe Multitargets Pharmacological Mechanism of Qishenkeli Acting on the Coronary Heart Disease
Joint Authors
Liu, Zhongyang
Li, Chun
Li, Dong
Ouyang, Yulin
Yu, Junda
Guo, Shuzhen
He, Fuchu
Wang, Wei
Wang, Yong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In this paper, we present a case study of Qishenkeli (QSKL) to research TCM’s underlying molecular mechanism, based on drug target prediction and analyses of TCM chemical components and following experimental validation.
First, after determining the compositive compounds of QSKL, we use drugCIPHER-CS to predict their potential drug targets.
These potential targets are significantly enriched with known cardiovascular disease-related drug targets.
Then we find these potential drug targets are significantly enriched in the biological processes of neuroactive ligand-receptor interaction, aminoacyl-tRNA biosynthesis, calcium signaling pathway, glycine, serine and threonine metabolism, and renin-angiotensin system (RAAS), and so on.
Then, animal model of coronary heart disease (CHD) induced by left anterior descending coronary artery ligation is applied to validate predicted pathway.
RAAS pathway is selected as an example, and the results show that QSKL has effect on both rennin and angiotensin II receptor (AT1R), which eventually down regulates the angiotensin II (AngII).
Bioinformatics combing with experiment verification can provide a credible and objective method to understand the complicated multitargets mechanism for Chinese herbal formula.
American Psychological Association (APA)
Wang, Yong& Liu, Zhongyang& Li, Chun& Li, Dong& Ouyang, Yulin& Yu, Junda…[et al.]. 2012. Drug Target Prediction Based on the Herbs Components: The Study onthe Multitargets Pharmacological Mechanism of Qishenkeli Acting on the Coronary Heart Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028483
Modern Language Association (MLA)
Wang, Yong…[et al.]. Drug Target Prediction Based on the Herbs Components: The Study onthe Multitargets Pharmacological Mechanism of Qishenkeli Acting on the Coronary Heart Disease. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028483
American Medical Association (AMA)
Wang, Yong& Liu, Zhongyang& Li, Chun& Li, Dong& Ouyang, Yulin& Yu, Junda…[et al.]. Drug Target Prediction Based on the Herbs Components: The Study onthe Multitargets Pharmacological Mechanism of Qishenkeli Acting on the Coronary Heart Disease. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028483