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Caffeic Acid Phenethyl Ester Inhibits Oral Cancer Cell Metastasis by Regulating Matrix Metalloproteinase-2 and the Mitogen-Activated Protein Kinase Pathway
المؤلفون المشاركون
Lin, Chiao-Wen
Peng, Chih-Yu
Yang, Hui-Wen
Chu, Yin-Hung
Chang, Yu-Chao
Chou, Ming-Yung
Lin, Yueh-Min
Yang, Shun-Fa
Hsieh, Ming-Ju
Yeh, Kun-Tu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Caffeic acid phenethyl ester (CAPE), an active component extracted from honeybee hives, exhibits anti-inflammatory and anticancer activities.
However, the molecular mechanism by which CAPE affects oral cancer cell metastasis has yet to be elucidated.
In this study, we investigated the potential mechanisms underlying the effects of CAPE on the invasive ability of SCC-9 oral cancer cells.
Results showed that CAPE attenuated SCC-9 cell migration and invasion at noncytotoxic concentrations (0 μM to 40 μM).
Western blot and gelatin zymography analysis findings further indicated that CAPE downregulated matrix metalloproteinase-2 (MMP-2) protein expression and inhibited its enzymatic activity.
CAPE exerted its inhibitory effects on MMP-2 expression and activity by upregulating tissue inhibitor of metalloproteinase-2 (TIMP-2) and potently decreased migration by reducing focal adhesion kinase (FAK) phosphorylation and the activation of its downstream signaling molecules p38/MAPK and JNK.
These data indicate that CAPE could potentially be used as a chemoagent to prevent oral cancer metastasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peng, Chih-Yu& Yang, Hui-Wen& Chu, Yin-Hung& Chang, Yu-Chao& Hsieh, Ming-Ju& Chou, Ming-Yung…[et al.]. 2012. Caffeic Acid Phenethyl Ester Inhibits Oral Cancer Cell Metastasis by Regulating Matrix Metalloproteinase-2 and the Mitogen-Activated Protein Kinase Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028510
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peng, Chih-Yu…[et al.]. Caffeic Acid Phenethyl Ester Inhibits Oral Cancer Cell Metastasis by Regulating Matrix Metalloproteinase-2 and the Mitogen-Activated Protein Kinase Pathway. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028510
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peng, Chih-Yu& Yang, Hui-Wen& Chu, Yin-Hung& Chang, Yu-Chao& Hsieh, Ming-Ju& Chou, Ming-Yung…[et al.]. Caffeic Acid Phenethyl Ester Inhibits Oral Cancer Cell Metastasis by Regulating Matrix Metalloproteinase-2 and the Mitogen-Activated Protein Kinase Pathway. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028510
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028510
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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