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Caffeic Acid Phenethyl Ester Inhibits Oral Cancer Cell Metastasis by Regulating Matrix Metalloproteinase-2 and the Mitogen-Activated Protein Kinase Pathway
Joint Authors
Lin, Chiao-Wen
Peng, Chih-Yu
Yang, Hui-Wen
Chu, Yin-Hung
Chang, Yu-Chao
Chou, Ming-Yung
Lin, Yueh-Min
Yang, Shun-Fa
Hsieh, Ming-Ju
Yeh, Kun-Tu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Caffeic acid phenethyl ester (CAPE), an active component extracted from honeybee hives, exhibits anti-inflammatory and anticancer activities.
However, the molecular mechanism by which CAPE affects oral cancer cell metastasis has yet to be elucidated.
In this study, we investigated the potential mechanisms underlying the effects of CAPE on the invasive ability of SCC-9 oral cancer cells.
Results showed that CAPE attenuated SCC-9 cell migration and invasion at noncytotoxic concentrations (0 μM to 40 μM).
Western blot and gelatin zymography analysis findings further indicated that CAPE downregulated matrix metalloproteinase-2 (MMP-2) protein expression and inhibited its enzymatic activity.
CAPE exerted its inhibitory effects on MMP-2 expression and activity by upregulating tissue inhibitor of metalloproteinase-2 (TIMP-2) and potently decreased migration by reducing focal adhesion kinase (FAK) phosphorylation and the activation of its downstream signaling molecules p38/MAPK and JNK.
These data indicate that CAPE could potentially be used as a chemoagent to prevent oral cancer metastasis.
American Psychological Association (APA)
Peng, Chih-Yu& Yang, Hui-Wen& Chu, Yin-Hung& Chang, Yu-Chao& Hsieh, Ming-Ju& Chou, Ming-Yung…[et al.]. 2012. Caffeic Acid Phenethyl Ester Inhibits Oral Cancer Cell Metastasis by Regulating Matrix Metalloproteinase-2 and the Mitogen-Activated Protein Kinase Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028510
Modern Language Association (MLA)
Peng, Chih-Yu…[et al.]. Caffeic Acid Phenethyl Ester Inhibits Oral Cancer Cell Metastasis by Regulating Matrix Metalloproteinase-2 and the Mitogen-Activated Protein Kinase Pathway. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028510
American Medical Association (AMA)
Peng, Chih-Yu& Yang, Hui-Wen& Chu, Yin-Hung& Chang, Yu-Chao& Hsieh, Ming-Ju& Chou, Ming-Yung…[et al.]. Caffeic Acid Phenethyl Ester Inhibits Oral Cancer Cell Metastasis by Regulating Matrix Metalloproteinase-2 and the Mitogen-Activated Protein Kinase Pathway. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028510