Effects of Rhizophora mangle on Experimental Colitis Induced by TNBS in Rats
المؤلفون المشاركون
Vilegas, Wagner
Rozza, A. L.
Socca, Eduardo Augusto Rabelo
de Almeida, Ana Cristina Alves
Manzo, Luis Paulo
da Silva, Marcelo Aparecido
dos Santos, Lourdes Campaner
Souza Brito, Alba Regina Monteiro
Luiz-Ferreira, Anderson
de-Faria, Felipe Meira
Dunder, Ricardo José
Pellizzon, Cláudia Helena
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Male Unib-WH rats were pretreated for two weeks with butanolic (BuOH) and ethyl acetate (EtOAc) fractions.
Colitis was induced by rectal administration of TNBS, the treatment continued, and animals were sacrificed on day 7 after the TNBS administration.
Phytochemical studies were performed in order to provide the characterization of the tannins present in the bark of R.
mangle.
Results showed that EtOAc fraction increased the levels of IL-10 (**P<0.01) and diminished the levels of TNF-α (***P<0.001) and IL-6 (**P<0.01).
BuOH fraction reduced the MPO activity (**P<0.01) and levels of TBARS (***P<0.001); it also increased COX-1 expression, diminished the levels of TNF-α (***P<0.001), and increased the levels of IL-12 (***P<0.001).
Besides, both treatments augmented the levels of GSH (*P<0.05), the activity of GSH-Px (**P<0.01 for BuOH fraction and ***P<0.001 for EtOAc fraction), and CAT (**P<0.01).
In conclusion, both treatments ameliorated the injury induced by TNBS through different mechanisms, probably by their chemical composition which directed its activity into an antioxidant or anti-inflammatory response, leading to an immune modulation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de-Faria, Felipe Meira& Luiz-Ferreira, Anderson& Socca, Eduardo Augusto Rabelo& de Almeida, Ana Cristina Alves& Dunder, Ricardo José& Manzo, Luis Paulo…[et al.]. 2012. Effects of Rhizophora mangle on Experimental Colitis Induced by TNBS in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028526
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de-Faria, Felipe Meira…[et al.]. Effects of Rhizophora mangle on Experimental Colitis Induced by TNBS in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028526
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de-Faria, Felipe Meira& Luiz-Ferreira, Anderson& Socca, Eduardo Augusto Rabelo& de Almeida, Ana Cristina Alves& Dunder, Ricardo José& Manzo, Luis Paulo…[et al.]. Effects of Rhizophora mangle on Experimental Colitis Induced by TNBS in Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028526
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028526
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر