Effects of Rhizophora mangle on Experimental Colitis Induced by TNBS in Rats
Joint Authors
Vilegas, Wagner
Rozza, A. L.
Socca, Eduardo Augusto Rabelo
de Almeida, Ana Cristina Alves
Manzo, Luis Paulo
da Silva, Marcelo Aparecido
dos Santos, Lourdes Campaner
Souza Brito, Alba Regina Monteiro
Luiz-Ferreira, Anderson
de-Faria, Felipe Meira
Dunder, Ricardo José
Pellizzon, Cláudia Helena
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Male Unib-WH rats were pretreated for two weeks with butanolic (BuOH) and ethyl acetate (EtOAc) fractions.
Colitis was induced by rectal administration of TNBS, the treatment continued, and animals were sacrificed on day 7 after the TNBS administration.
Phytochemical studies were performed in order to provide the characterization of the tannins present in the bark of R.
mangle.
Results showed that EtOAc fraction increased the levels of IL-10 (**P<0.01) and diminished the levels of TNF-α (***P<0.001) and IL-6 (**P<0.01).
BuOH fraction reduced the MPO activity (**P<0.01) and levels of TBARS (***P<0.001); it also increased COX-1 expression, diminished the levels of TNF-α (***P<0.001), and increased the levels of IL-12 (***P<0.001).
Besides, both treatments augmented the levels of GSH (*P<0.05), the activity of GSH-Px (**P<0.01 for BuOH fraction and ***P<0.001 for EtOAc fraction), and CAT (**P<0.01).
In conclusion, both treatments ameliorated the injury induced by TNBS through different mechanisms, probably by their chemical composition which directed its activity into an antioxidant or anti-inflammatory response, leading to an immune modulation.
American Psychological Association (APA)
de-Faria, Felipe Meira& Luiz-Ferreira, Anderson& Socca, Eduardo Augusto Rabelo& de Almeida, Ana Cristina Alves& Dunder, Ricardo José& Manzo, Luis Paulo…[et al.]. 2012. Effects of Rhizophora mangle on Experimental Colitis Induced by TNBS in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028526
Modern Language Association (MLA)
de-Faria, Felipe Meira…[et al.]. Effects of Rhizophora mangle on Experimental Colitis Induced by TNBS in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028526
American Medical Association (AMA)
de-Faria, Felipe Meira& Luiz-Ferreira, Anderson& Socca, Eduardo Augusto Rabelo& de Almeida, Ana Cristina Alves& Dunder, Ricardo José& Manzo, Luis Paulo…[et al.]. Effects of Rhizophora mangle on Experimental Colitis Induced by TNBS in Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028526