Curative Effects of Oleanolic Acid on Formed Hypertrophic Scars in the Rabbit Ear Model
المؤلفون المشاركون
Jiang, Yiping
Zhang, Hong
Zhang, Yan
Han, Hai-Yan
Peng, Cheng
He, Kun
Qin, Lu-Ping
Rahman, Khalid
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Hypertrophic scarring is a common proliferative disorder of dermal fibroblasts characterized by collagen overproduction and excessive deposition of extracellular matrix (ECM).
There is no consensus about the best therapeutics to produce complete and permanent improvement of scars with few side effects.
To investigate the therapeutic effects of oleanolic acid (OA) on hypertrophic scars and explore the possible mechanism of action involved, a rabbit ear model with hypertrophic scars was established.
OA (2.5%, 5%, and 10%) was given once daily to the scars for 28 consecutive days.
As a result, OA significantly alleviated formed hypertrophic scars on rabbit ears.
The levels of TGF-β1, MMP-1, TIMP-1, and collagens I and III were notably decreased, and the number of apoptosis cells and mRNA expression of MMP-2, caspase-3, and caspase-9 were markedly increased in the scar tissue.
The scar elevation index (SEI) was also evidently reduced.
Histological findings exhibited significant amelioration of the collagen tissue.
These results suggest that OA has the favorable curative effects on formed hypertrophic scars in the rabbit ear model, and the possible mechanism of action is that OA decreases HSFs proliferation and increases HSFs apoptosis by reduction of P311 gene expression and TGF-β1 production, inhibition of TIMP-1 secretion, enhancement of MMP-2 activity, and subsequently facilitation of degradation of collagen types I and III.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Hong& Zhang, Yan& Jiang, Yiping& Han, Hai-Yan& Peng, Cheng& He, Kun…[et al.]. 2012. Curative Effects of Oleanolic Acid on Formed Hypertrophic Scars in the Rabbit Ear Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028574
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Hong…[et al.]. Curative Effects of Oleanolic Acid on Formed Hypertrophic Scars in the Rabbit Ear Model. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028574
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Hong& Zhang, Yan& Jiang, Yiping& Han, Hai-Yan& Peng, Cheng& He, Kun…[et al.]. Curative Effects of Oleanolic Acid on Formed Hypertrophic Scars in the Rabbit Ear Model. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028574
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028574
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر